Pengaruh Metabolit Tumor Akibat Sindrom Tumor Lisis pada Terjadinya Gagal Ginjal Akut Serta pada Anak
Sari
Sindrom tumor lisis merupakan triad kelainan metabolik (hiperurisemia, hiperfosfatemia,
hiperkalemia) yang sering terjadi pada pasien keganasan akibat sel-sel tumor lisis secara
cepat baik secara spontan ataupun karena pengobatan anti kanker. Metabolit tumor
(asam urat, fosfor, kalium) semuanya diekskresi oleh ginjal sehingga sering menimbulkan
komplikasi pada ginjal. Komplikasi tersering adalah gagal ginjal akut, hal ini memerlukan
perhatian yang serius karena lebih mudah dicegah daripada diobati.
Kata Kunci
Teks Lengkap:
PDFReferensi
Kelly KM, Lange B. Oncologic emergencies. Pediatic
Clin North Am 1997; 274: 809-30.
Lanore JJ, Brunet F, Pochard F. Hemodialysis for acute
renal failure in patients with hematologic malignancies.
Critical Care Medicine 1991; 19: 346-51.
Stapleton FB, Strother DR, Roy S, Wyatt RJ, McKay
CP, Murphy SB. Acute renal failure at onset of therapy
for advanced stage Burkitt limphoma and B cell acute
lymphoblastic lymphoma. Pediatrics 1988; 82: 863-
Foerster J. Multiple myeloma. Dalam: Lee GR, Bithell
TC, Foerster J, Athens JW, Lukens JN, Penyunting.
Wintrobe’s clinical hematology. Edisi ke-9. Philadelphia:
Lea & Febiger; 1993. h. 2219-40.
Sodeman WA, Sodeman TM. Multiple mieloma. Dalam:
Joko S, penyunting. Sodeman Patofisiologi. Edisi ke-7.
Jilid II. Jakarta: Hippocrates; 1991. h. 289-91.
Kher KK. Evaluation of renal functions. Dalam: Kher
KK, Makker SP, Penyunting. Clinical Pediatric Nephrology.
Singapore: McGraw-Hill; 1992. h. 3-22.
Rauf S. Nefropati toksik. Dalam: Alatas S, Tambunan
T, Trihono PP, Penyunting. Buku ajar Nefrologi Anak
jilid 2. Jakarta: Balai Penerbit Fakultas Kedokteran Universitas
Indonesia; 1996. h. 415-25.
Lange B, Junior JAO, Goldwein JW, Packer RJ, Ross
AJ. Oncologic emergencies. Dalam: Pizzo PA, Poplack
DG, penyunting. Principles and practice of pediatric
oncology. Edisi ke-3. Philadelphia: Lippincott; 1997.
h. 1025-46.
Tumor lysis syndrome. Didapat dari: URL: http://
www.emedicine.com/ped/topic2328.htm
Lanzkowsky P, penyunting. Manual of pediatric hematology
and oncology. Edisi kedua. United States of
America: Churchill Livingstone; 1995. h. 579-83.
Oncologic emergencies. Didapat dari: URL: http://
www.vnh.org/pediatric Emergencymanual/oncologic.html.
Pinkerton CB Emergencies and supportive care. Dalam:
Pinkerton CB, Cushing P, Sepion B. A practical handbook
childhood cancer management. London; Chapman
& Hall ; 1994. h. 203-11.
Garnick MB, Mayer RJ. Management of acute renal
failure associated with neoplastic disease. Dalam: Yarbro
JW, Bornstein RS, penyunting. Oncologic emergencies.
New York: Grune & Stratton; 1986. h. 247-71.
Bock GH. Acute renal failure. Dalam: Kher KK, Makker
SP, Penyunting. Clinical Pediatric Nephrology.
Singapore. McGraw-Hill; 1992. h. 469-97.
Yoel C. Pengelolaan gagal ginjal akut pada anak.
Simposium Nasional Nefrologi Anak ke-5 dan
simposium Nasional Pediatri Gawat Darurat ke-2;
Medan, Sumatera utara; 1992.
Andreoli SP, Clark JH, McGuire WA, Bergstein JM.
Purine excretion during tumor lysis in children with
acute lymphocytic leukemia receiving allopurinol: relationship
to acute renal failure. J Peditr 1986; 109:292-
Shad A, Magrath I. Malignant non Hodgkin’s lymphomas
in children. Dalam: Pizzo PA, Poplack DG,
penyunting. Principles and practice of pediatric oncology.
Edisi ke-3. Philadelphia: Lippincott; 1997. h. 545-
Moorthy AV, Chesney RW. Renal and metabolic effects
of extrarenal neoplasms. Dalam: Edelmann CM,
Bernstein J, penyunting. Pediatric Kidney disease. Edisi
ke-2. Boston: Little Brown; 1992. h. 1557-68.
Baldree LA, Stapleton FB. Uric acid metabolism in children.
Pediatric Clin North Am 1990; 37:391-418.
Goldman SC, Holcenberg JS, Finklestein JZ, dkk.
A randomised comparison between rasburicase and
allopurinol in children with lymphoma or leukemia
at high risk for tumor lysis. Blood 2001; 97:2998-
Pui CH, Mahmoud H, Wiley JM. Recombinant urate
oxidase for the prophylaxis or treatment of hyperuricema
in patient with leukemia or lymphoma. J of Clin Oncology
; 19:697-704.
DOI: http://dx.doi.org/10.14238/sp7.2.2005.93-6
Refbacks
- Saat ini tidak ada refbacks.
##submission.copyrightStatement##
##submission.license.cc.by-nc-sa4.footer##
Email: editorial [at] saripediatri.org
Sari Pediatri diterbitkan oleh Badan Penerbit Ikatan Dokter Anak Indonesia
Ciptaan disebarluaskan di bawah Lisensi Creative Commons Atribusi-NonKomersial-BerbagiSerupa 4.0 Internasional.