Dampak Suplementasi Besi dan Seng dalam Meningkatkan Eritropoiesis pada Malaria Anak yang Diberi Obat Anti Malaria di Daerah Endemis
Sari
Latar belakang. Dampak besi dan seng untuk anak pasien malaria pada daerah endemis telah diteliti
dapat menurunkan parasitemia. Namun penelitian interaksi keduanya bila diberikan bersama-sama untuk
meningkatkan kadar hemoglobin, serum feritin, dan retikulosit masih terbatas.
Tujuan. Membandingkan dampak seng dalam meningkatkan absorbsi besi pada anak dengan malaria falciparum
yang mendapat pengobatan.
Metode. Subjek dibagi menjadi dua kelompok yaitu kelompok besi ditambah plasebo dan kelompok besi
ditambah seng kemudian darah vena diambil sebelum perlakuan (H0) dan pada akhir penelitian (H30).
Hasil. Setelah 30 hari suplementasi, 69 anak dapat menyelesaikan penelitian dan memenuhi kriteria untuk
dapat dianalisis. Terdapat perubahan yang bermakna pada konsentrasi hemoglobin kelompok besi ditambah
plasebo dan kelompok besi ditambah seng setelah suplementasi (0,58 dan 0,09 g/dl; p<0,05) tetapi serum
feritin dan retikulosit tidak bermakna.
Kesimpulan. Suplementasi besi dan seng hanya meningkatkan kadar hemoglobin pada anak penderita
malaria di daerah endemis yang diberi obat anti malaria
Kata Kunci
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DOI: http://dx.doi.org/10.14238/sp10.1.2008.1-7
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