Prevalens dan Sebaran Faktor Risiko Mikosis Sistemik pada Neonatus dengan Sepsis Awitan Lambat di RS Dr. Cipto Mangunkusumo
Sari
Latar belakang. Infeksi jamur sistemik merupakan salah satu penyebab morbiditas dan mortalitas pada
neonatus dengan gejala klinis yang mirip dengan sepsis. Mengetahui prevalens, pola jamur, faktor risiko,
profil klinis, terapi, dan luaran klinis diharapkan dapat mengurangi morbiditas dan mortalitas infeksi jamur
pada neonatus.
Tujuan. Mengetahui prevalens dan faktor risiko mikosis sistemik pada neonatus dengan sepsis awitan
lambat.
Metode. Studi potong lintang retrospektif dengan penelusuran rekam medis Departemen Ilmu Kesehatan
Anak sejak bulan Januari 2005- Desember 2008.
Hasil. Seratus empat puluh satu neonatus mengalami sepsis awitan lambat, 10 subjek tidak memenuhi
kriteria inklusi sehingga terdapat 131 subjek yang dapat dianalisis. Lima puluh lima (42%) subjek terbukti
mengalami infeksi mikosis sistemik. Manifestasi klinis yang mencolok adalah infeksi pada sistem respirasi
dan gastrointestinal. Faktor risiko infeksi jamur yang ditemukan pada studi ini adalah pemasangan kateter
intravena, nutrisi parenteral, dan masa rawat lama. Profil laboratorium yang jelas adalah trombositopeni,
CRP> 10, dan rasio IT >0,2. Setelah dilakukan analisis multivariat dan regresi logistik maka faktor risiko
yang bermakna adalah muntah, tidak diare, dan masa rawat lama.
Kesimpulan.Prevalens infeksi jamur sistemik pada sepsis awitan lambat 42% dengan penyebab Candida sp. Faktor
risiko yang bermakna adalah muntah, tidak diare, dan masa rawat lama.Â
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DOI: http://dx.doi.org/10.14238/sp11.4.2009.229-37
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