Antibodi Anti DS-DNA Sebagai Faktor Prognosis Mortalitas pada Lupus Erimatosus Sistemik
Sari
Latar belakang.Angka kejadian lupus eritematosus sistemik (LES) di RSUP Dr Sardjito meningkat dengan
mortalitas tinggi. Antibodi anti double stranded-DNA (ds- DNA ) merupakan antibodi patognomonik
pada SLE.
Tujuan.Mengetahui hubungan antara antibodi anti ds-DNA dengan mortalitas pasien SLE.
Metode.Penelitian kohort retrospektif terhadap pasien SLE yang berusia kurang dari 18 tahun yang
didapatkan secara konsekutif. Survivaldihitung menggunakan metode Kaplan Meier. Analisis log rankdan
regresi Coxdigunakan untuk mengidentifikasi faktor yang berhubungan dengan mortalitas.
Hasil.Didapatkan 46 pasien ikutserta dalam penelitian, 8 (17,4%) laki-laki dan 38 (82,6%) perempuan
dengan rerata usia terdiagnosis 11,9 tahun, 21 subyek (45,7%) diantaranya meninggal. Survivalpada tahun
pertama, ketiga dan kelima adalah 85%, 60%, dan 30 %. Rerata waktu follow uppasien dengan antibodi
anti ds-DNA sebesar 885,5 hari (IK 95% 631,9–1139,1) tampak lebih pendek secara bermakna dibanding
pasien dengan antibodi anti ds DNA negatif 4807,5 (IK 95% 4025,4–5389,0). Analisis multivariat menunjukkan antibodi anti ds-DNA merupakan satu – satunya faktor prognostik terhadap mortalitas pasien
SLE (hazard ratio6,7; IK 95% 1,38–12,40).
Kesimpulan.Antibodi anti ds-DNA merupakan faktor prognosis terhadap mortalitas pasien SLE.
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DOI: http://dx.doi.org/10.14238/sp14.2.2012.90-6
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