Penilaian Aktivitas Penyakit Lupus Eritematosus Sistemik dengan Skor SLEDAI di Departemen Ilmu Kesehatan Anak RSCM

Anisah M. Saleh, Nia Kurniati, Badriul Hegar Syarif

Sari


Latar belakang. Keberhasilan tata laksana penyakit lupus eritematosus sistemik (LES) memerlukan
pemantauan tertentu. Skor systemic lupus erythematosus disease activity index (SLEDAI) adalah alat ukur
yang dapat digunakan untuk tata laksana sehari-hari. Saat ini belum ada data mengenai pemantauan aktivitas
penyakit LES anak menggunakan skor SLEDAI dengan rentang waktu tertentu.
Tujuan. Memantau aktivitas penyakit LES anak dengan skor SLEDAI setiap 3 bulan selama satu tahun
pengamatan.
Metode. Studi deskriptif retrospektif menggunakan data rekam medik dari 01 Juli 2005 sampai dengan
31 Juli 2013.
Hasil. Tigapuluh rekam medik memenuhi kriteria penelitian. Manifestasi awal tersering berdasarkan skor
SLEDAI adalah artritis, rash, demam, peningkatan dsDNA, dan komplemen darah rendah. Perubahan skor
SLEDAI terutama terlihat pada pengamatan antara bulan ke-0 dengan bulan ke-3. Pada awal pengamatan,
mayoritas pasien termasuk high activity, tetapi pada akhir pengamatan menjadi no activity.
Kesimpulan. Penilaian skor SLEDAI setiap 3 bulan dapat digunakan untuk memantau aktivitas penyakit
LES anak.


Kata Kunci


lupus eritematosus sistemik; aktivitas penyakit; SLEDAI

Teks Lengkap:

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Referensi


Akib AAP, Soepriadi M, Setiabudiawan B. Lupus

eritematosussistemik. Dalam: Akib AAP, Munasir Z,

Kurniati N, penyunting. Buku ajar alergi-imunologi

anak. Edisi kedua. Jakarta: Badan Penerbit IDAI; 2008.

h.346-73.

Gitelman MSK, Miller ML. Systemic lupus erythematosus.

Dalam: Behrman RE, Kliegman RM, Jenson

HB, penyunting. Nelson textbook of pediatrics. Edisi

ke–17. Philadelphia: Saunders; 2004.h.809-13.

Lam GKW dan Petri M. Assessment of systemic lupus

erythematosus. Clin Exp Rheumatol 2005;23Supl39:

-32.

Lehman TJA. Systemic lupus erythematosus in

childhood and adolescence. Dalam: Wallace DJ,

Hahn BH, penyunting. Dubois’ lupus erythematosus.

Edisi ke-7. Philadelphia: Lippincott Williams and

Wilkins;2007.h.848-66.

Alatas H. Nefritis lupus. Dalam: Alatas H, Tambunan T,

Trihono PP, Pardede SO, penyunting. Buku ajar nefrologi

anak. Jakarta: Balai Penerbit FKUI;2004.h.366-80.

Petty RE, Laxer RM. Systemic lupus erythematosus.

Dalam: Cassidy JT, Petty RE, penyunting. Textbook of

pediatric rheumatology. Edisi ke-5. Philadelphia: Elsevier

Saunders; 2005.h.342-91.

Sudewi NP, Kurniati N, Suyoko EMD, Munasir Z, Akib

AAP. Karakteristik klinis lupus eritematosus sistemik

pada anak. Sari Pediatri 2009;11:108-12.

Gladdman DD, Goldsmith CH, Urowitz MB, Bacon P,

Bombardier C, Isenberg D, dkk. Sensitivity to change of

systemic lupus erythematosus disease activity indices: international validation. J Rheumatol 1994;21:1468-

Brunner HI, Silverman ED, Bombardier C, Feldman

BM. European consensus lupus activity measurement

is sensitive to change in disease activity in childhoodawitan

systemic lupus erythematosus.Arthritis Rheum

;49:335-341.

Yee CS, Isenberg DA, Prabu A, Sokoll K, The LS,

Rahman A, dkk. BILAG-2004 index captures systemic

lupus erythematosus disease activity better than

SLEDAI-2000. Ann Rheum Dis 2008;67:873-6.

Brunner HI, Feldman BM, Bombardier C, Silverman ED.

Sensitivity of the systemic lupus erythematosus disease

activity index, British isles lupus assessment group index,

and systemic lupus activity measure in the evaluation

of clinical change in childhood onset systemic lupus

erythematosus. Arthritis Rheum1999;42:1354-60.

Khanna S, Pal H, Pandey RM, Handa R. The relationship

between disease activity and quality of life in systemic

lupus erythematosus. J Rheumatol 2004;43:1536-40.

Mosca M, Bombardieri S. Assessing remission in systemic

lupus erythematosus. Clin Exp Rheumatol 2006;24Supl

:S100-S104.

Ibanez D, Gladman DD, Touma Z, Nikpour M,

Urowitz MB. Optimal frequency of visits for patients

with systemic lupus erythematosus to measure disease

activity over time. J Rheumatol 2011;38:60-3.

Gomez LAR, Uribe OU, Uribe OO, Romero HG,

Cardiel MH, Wojdyla D, dkk. Childhood systemic lupus

erythematosus in latinamerica: the gladel experience in

children. Lupus 2008;17:596-604.

Gulay CB, Dans LF. Clinical presentations and outcomes

of filipino juvenile systemic lupus erythematosus. Ped

Rheum 2011;9:1-7

Muzaffer MA dan Al-Mayouf SM. Clinical and laboratory

variables of childhood systemic lupus erythematosus

in western province of Saudi Arabia. Rheumatol Int

;31:23-26.

Bakr A. Epidemiology treatment and outcome of

childhood systemic lupus erythematosus in Egypt.

Pediatr Nephrol 2005;20:1081-6.

Gonzalez B, Hernandez P, Olguin H, Miranda M, Lira

L, Toso M, dkk. Changes in the survival of patients with

systemic lupus erythematosus in childhood: 30 years

experience in chile. Lupus 2005;14:918-23.

FitzGerald JD dan Grossman JM. Validity and reliability

of retrospective assessment of disease activity and flare

in observational cohorts of lupus patients. Lupus

;8:638-44.

Dung NTN, Loan HT, Nielsen S, Zak M, Petersen FK.

Juvenile systemic lupus erythematosus awitan patterns in

vietnamese children: a descriptive study of 45 children.

Pediatr Rheum 2012;10:38-44.

Hiraki LT, Benseler M, Tyrrell PN, Hebert D,

Harvey E, Silverman ED. Clinical and laboratory

characteristics and long-term outcome of pediatric

systemic lupus erythematosus: a longitudinal study. J

Pediatr 2008;152:550-6

Benseler SM dan Silverman ED. Systemis lupus

erythematosus. Pediatr Clin Am 2005;52:443-67.

Gottlieb BS, Ilowite NT. Systemic lupus erythematosus

in children and adolescents. Pediatr in Rev 2006;27:323-

Barr SG, Zonana-Nacach A, Magder LS, Petri M. Patterns

of disease activity in systemic lupus erythematosus.

Arthritis Rheum 1999;42:2682-8.

Brunner HI, Gladman DD, Ibanez D, Urowitz MD,

Silverman ED. Difference in disease features between

childhood-onset and adult-onset systemic lupus

erythematosus. Arthritis Rheum 2008;58:556-62.




DOI: http://dx.doi.org/10.14238/sp16.4.2014.292-8

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