Retinol Binding Protein dan Luaran Pascabedah
Sari
Latar belakang. Malnutrisi sering ditemukan pada pascabedah dan berhubungan dengan luaran yang tidak
baik, seperti sepsis atau infeksi luka operasi. Retinol binding protein (RBP) merupakan parameter biokimia
yang cukup reliabel untuk menilai malnutrisi.
Tujuan. Mengetahui pengaruh malnutrisi berdasarkan penurunan RBP terhadap luaran pasien
pascabedah
Metode. Penelitian observasional analitik dilakukan di ICU Anak tiga rumah sakit yakni RS Cipto
Mangunkusumo, RSUP Dr. Kariadi, dan RSUD Dr. Moewardi. Dilakukan pengukuran RBP, kortisol,
CRP pada hari pertama dan kelima pascabedah. Luaran infeksi dinilai berdasarkan skor ASEPSIS. Analisis
bivariat dilakukan terhadap beberapa faktor risiko dengan kejadian infeksi luka operasi dan sepsis. Analisis
data menggunakan program SPSS versi 17.00.
Hasil. Selama kurun waktu 6 bulan, 39 subjek memenuhi kriteria inklusi, tetapi 4 tidak melanjutkan
penelitian. Penurunan kadar RBP hari kelima pascabedah 34,3% kasus. Penurunan RBP, CRP, usia <1
tahun, dan skor ASA ô€´3 berisiko mendapatkan infeksi luka operasi berturut-turut 4,4; 3,3;1,2; dan 1,3 kali
dengan nilai p>0,05 dan 95% IK masing-masing (0,35-54,4; 0,3 – 40,8;0,1-15,8; dan 0,97-1,6). Faktor
lain-status nutrisi prabedah, lama pembedahan, kategori luka operasi dan kortisol-juga didapatkan hasil
yang tidak signifikan. Penelitian ini tidak mendapatkan luaran sepsis.
Kesimpulan. Terdapat risiko terjadi infeksi luka operasi 4,4 kali apabila kadar RBP menurun, 3,3 kali
apabila CRP meningkat, 1,2 kali apabila usia <1 tahun, dan 1,3 kali apabila skor ASA ô€´3, tetapi secara
statistik tidak ada perbedaan bermakna.
Kata Kunci
Teks Lengkap:
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DOI: http://dx.doi.org/10.14238/sp16.4.2014.271-7
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