Neutrophil Gelatinase Associated Lipocalin Urin sebagai Deteksi Dini Acute Kidney Injury
Sari
Latar belakang. Penelitian terkini fokus pada identifikasi biomarker yang lebih dini untuk acute kidney injury (AKI). Salah satunya adalah neutrophil gelatinase associated lipocalin (NGAL), protein 25 kDa yang merupakan potensial biomarker dini untuk AKI.
Tujuan. Melihat neutrophil gelatinase associated lipocalin (NGAL) sebagai biomarker dini untuk acute kidney injury (AKI).
Metode. Penelitian kualitatif dengan desain uji diagnostik. Pengambilan sampel secara cross sectional dan consecutive sampling pada 50 orang anak, terdiri atas 28 sepsis dan 22 sepsis berat di ruang rawat intensif anak di RS. Cipto Mangunkusomo Jakarta dan RS. Wahidin Sudirohusodo Makassar.
Hasil. Terdapat perbedaan sangat bermakna kadar NGAL urin dan kreatinin berdasarkan beratnya sepsis (p<0,001). Nilai rerata sepsis 132,93 ng/mL dan sepsis berat 2159,98 ng/mL. Terdapat perbedaan bermakna antara beratnya AKI menurut kriteria RIFFLE dengan beratnya sepsis (p=0,013). Tidak terdapat hubungan bermakna antara kadar NGAL urin dengan kriteria RIFFLE (p=0,173). Nilai sensitifitas NGAL urin 100% dan spesifisitas 63,63%, positive predictive value 27,27%, negative predictive value 100% dan area under curve (AuOC) 0,826.
Kesimpulan. Neutrophil gelatinase associated lipocalin (NGAL) dapat dipakai sebagai skrining AKI.
Kata Kunci
Teks Lengkap:
PDFReferensi
Goldstein SL. Acute kidney injury in children and its potential consequences in adulthood. Blood Purif 2012;33:131-7.
Alatas H. Gagal ginjal akut. Dalam: Noer S, Asmaningsih N, Subandiyah K, dkk. Kompendium nefrologi anak. Jakarta: UKK Nefrologi IDAI; 2011.h.207-214.
Bagshaw SM, George C, Bellomo B. early acute kidney injury and sepsis: a multicentre evaluation. Crit Care 2008:1-9.
Huber W, Saugel B, Schmid RM, Gussmann W. Early detection of acute kidney injury in sepsis: how about NGAL? CLI, 2012. Diakses pada 13 Oktober 2014. Didapat dari: http://www.medizin.uni-tuebingen.de/kinder/de/abteilungen/neonatologie/Geschaeftsbericht% 202012.pdf.
Uttenthal O. NGAL: a marker molecule for the distress kidney. J CLI 2005:1-2.
Bolignano D, Donato V, Coppolino G, Campo S, Buemi A. Neutrophil gelatinase-associated (NGAL) as a marker kidney damage. Am J Kidney Dis 2008;52:595-605.
Clerico A, Galli C, Fortunato A, Ronco C. Neutrophil gelatinase-associated lipocalin (NGAL) as biomarker of acute kidney injury: a review of the laboratory characteristic and clinical evidences. Clin Chem Lab Med 2012;50:1505-17.
Nickolas TL, O’Rourke MJ, Yang J. Sensitivity and specificity of single emergency department measurement of urinary neutrophil gelatinase associated lipocalin for diagnosing acute kidney injury. Ann Intern Med 2008;148:810–819.
Morimatsu H, Egi M, amico GD. Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness. Intensive Care Med 2010;36:452-61.
Wheeler DS, Devarajan P, Ma Q, Harmon K. Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically III children with septic shock. Crit Care Med 2008;36:1297-303.
Zappitelli M, Wasburn KK, Arikan AA. Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically III children: A prospective Cohort Study. Crit Care 2007;11:1-11.
Morimatsu H, Egi M, amico GD. Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness. Intensive Care Med 2010;36:452-61.
Lentini P, Cal MD, Clemnti A, D’Angelo A. Sepsis and AKI in ICU patients: the role of plasma biomarker. Handawi Publishing Corporation. Crit Care Res Pract 2012;1-5.
DOI: http://dx.doi.org/10.14238/sp16.3.2014.195-200
Refbacks
- Saat ini tidak ada refbacks.
##submission.copyrightStatement##
##submission.license.cc.by-nc-sa4.footer##
Email: editorial [at] saripediatri.org
Sari Pediatri diterbitkan oleh Badan Penerbit Ikatan Dokter Anak Indonesia
Ciptaan disebarluaskan di bawah Lisensi Creative Commons Atribusi-NonKomersial-BerbagiSerupa 4.0 Internasional.