Gambaran Klinis dan Karakteristik Neonatus dari Ibu Terkonfimasi Covid-2019 di Rumah Sakit Dr. Soetomo

Risa Etika, Kartika Darma Handayani, Setya Mithra Hartiastuti, Virani Diana, Aminuddin Harahap, Oktavian Prasetya, Melinda Masturina

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Latar belakang. Penyakit Coronavirus 2019 (COVID-19) merupakan penyakit yang pertama kali dilaporkan di Wuhan, China dan telah menyebar ke seluruh dunia. Data ibu hamil dan bayi baru lahir belum banyak dipublikasikan.
Tujuan. Untuk mendeskripsikan gambaran dan karakteristik klinis neonatus yang lahir dari ibu dengan infeksi severe acute respiratory syndrome-coronavirus (SARS-CoV-2) perinatal.
Metode. Penelitian ini merupakan penelitian retrospektif yang dilaksanakan di ruang perawatan neonatal intensive care unit (NICU) Rumah Sakit Umum Daerah Dr.Soetomo Surabaya pada tanggal April - Oktober 2020. Populasi adalah neonatus yang lahir dari ibu terkonfimasi COVID-19 di di Rumah Sakit Dr. Soetomo Surabaya. Data diperoleh dari rekam medik.
Hasil. Total terdapat 109 ibu dengan hasil pemeriksaan positif reverse transcription - polymerase chain reaction (RT PCR) COVID-19, dan hanya 2 bayi dengan hasil RT-PCR COVID-19 positif. Usia rata-rata ibu hamil 28±5,9 tahun. Duapuluh sembilan bayi (26,61%) lahir kurang bulan. Cara persalinan didominasi oleh sectio caesaria sebanyak 64 ibu hamil (58,72%). Terdapat 23 bayi (21,11%) lahir dengan berat badan lahir <2500 gram dan 3 bayi dengan hasil negatif RT-PCR COVID-19 meninggal.
Kesimpulan. Saat ini belum terbukti adanya penularan secara vertikal COVID 19, sementara itu transmisi horizontal diperkirakan sebagai sumber infeksi pada neonatus. Penerapan protokol kesehatan terbukti efektif mencegah infeksi terhadap neonatus.

 


Kata Kunci


ibu konfirm Covid-19; luaran klinis neonatus; karakteristik klinis

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Referensi


Yu N, Li W, Kang Q, dkk. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single centre, descriptive study. Lancet Infect Dis 2020; 20:559-64.

Favre G, Pomar L, Musso D, Baud D. 2019-nCoV epidemic: what about pregnancies? Lancet 2020;395:e40.

Chen H, Guo J, Wang C, dkk. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020; 395:809–15.

Breslin N, Baptiste C, Gyamfi-Bannerman C, dkk. Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals. Am J Obstet Ggynecol 2020;2:100-18.

Allotey J, Stallings E, Bonet M, dkk. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ 2020;370:3320.

Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Coronavirus disease 2019 (COVID-19) and pregnancy: what obstetricians need to know. Am J Obstet Gynecol 2020;222:415-26 .

Karimi-Zarchia,M, Neamatzadehc,H, Dastgheibe SA. Vertical transmission of Coronavirus Disease 19 (COVID-19) from infected pregnant mothers to neonates: a review. Fetal Pediatr Pathol 2020;39:246-50.

Sheth S, Shah N, Bhandari V. Outcomes in COVID-19 positive neonates and possibility of viral vertical transmission: a narrative review. Am J Perinatol 2020;37:1208–16.

FAQs: management of infants born to mothers with suspected or confirmed COVID-19. Diakses 18 Juni 2020 Didapat dari:https://services.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/clinicalguidance/ faqs-management-of-infants-born-to-covid-19-mothers/.

Chawla D, Chirla D, Dalwai S, dkk. Perinatal-neonatal management of COVID-19 infection -guidelines of the federation of obstetric and gynaecological societies of India (FOGSI), National Neonatology Forum of India (NNF), and Indian Academy of Pediatrics (IAP). Indian Pediatr 2020;57:536-48.

Kalamdani P, Kalathingal T, Manerkar S, dkk. Clinical profile of SARS-CoV-2 infected neonates from a tertiary government hospital in Mumbai, India. Diakses 5 Januari 2021. Didapat dari: https://www.indianpediatrics.net/epub102020/RP-00250.pdf.

Storya L, Simpsonb NAB, David AL, dkk. Reducing the impact of preterm birth: preterm birth commissioning in the United Kingdom. Eur J Obstetr Gynecol Reproduct Biol 2019; 3: 100018.

Berkowitz K, LaSala A. Risk factors associated with the increasing prevalence of pneumonia during pregnancy. Am J Obstetr Gynecol 1990;163:981–5.

Schwartz DA, Graham AL. Potential maternal and infant outcomes from (Wuhan) Coronavirus 2019-nCoV infecting pregnant women: lessons from SARS, MERS, and other human coronavirus infections. Viruses 2020;12:194.

Turan O, Hakim A, Dashraath P. Clinical characteristics, prognostic factors, and maternal and neonatal outcomes of SARSâ€CoVâ€2 infection among hospitalized pregnant women: A systematic review. Int J Gynecol Obstet 2020;151:7–16.

De Bernardo G, Giordano M, Zollo G, dkk. The clinical course of SARS-CoV-2 positive neonates. J Perinatol 2020;40:1462-69.




DOI: http://dx.doi.org/10.14238/sp22.5.2021.285-9

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