Perbedaan Kadar Alpha 1 Antitrypsin Feses Berdasarkan Tingkat Keparahan Diare Akut pada Anak
Sari
Latar belakang. Diare dapat menyebabkan kekurangan gizi, gangguan pertumbuhan dan gangguan kognitif. Gangguan gizi dapat terjadi karena asupan makanan yang kurang, atau kehilangan langsung karena kerusakan mukosa usus. Kehilangan protein melalui saluran cerna dapat dinilai dengan pemeriksaan kadar alpha 1 antitrypsin feses.
Tujuan. Menilai perbedaan kadar alpha 1 antitrypsin feses berdasarkan tingkat keparahan diare akut pada anak.
Metode. Penelitian cross sectional dari Januari-Juli 2017. Penelitian dilakukan di RSUP Dr M Djamil dan RS Yos Sudarso Padang. Tingkat keparahan diare dinilai menggunakan Vesikari clinical severity scoring system. Kadar alpha 1 antitrypsin feses diperiksa dengan cara ELISA. Analisis statistik menggunakan uji Kruskal-Wallis.
Hasil. Dari 60 subjek penelitian, rerata kadar alpha 1 antitrypsin adalah 202,32 ± 131,96 mg/dL. Kadar alpha 1 antirypsin feses pada kelompok tingkat keparahan diare ringan didapatkan 123,6 (87-295,1) mg/dL. Pada kelompok tingkat keparahan diare sedang 166,4 (23,8-332,9) mg/dL dan kelompok tingkat keparahan diare berat 268,6 (25,5-511,9) mg/dL. Uji analisis statistik menunjukkan terdapat perbedaan kadar alpha 1 antitrypsin feses yang signifikan pada setiap tingkat keparahan diare dengan nilai p=0,003.
Kesimpulan. Terdapat peningkatan kadar alpha 1 anitripsin feses yang bermakna sesuai dengan tingkat keparahan diare.
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DOI: http://dx.doi.org/10.14238/sp19.5.2018.267-72
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