Perbedaan Kadar Feritin Serum Pada Penyandang Talasemia β Mayor yang Mengalami Hipotiroid dan Eutiroid
Sari
Latar belakang. Komplikasi penumpukan besi pada organ tiroid berupa hipotiroid. Sebagian besar penelitian yang meneliti hubungan feritin serum dan hipotiroid mendapatkan hasil yang tidak bermakna. Penumpukan besi pada organ dapat dipengaruhi oleh faktor genetik sehingga menyebabkan perbedaan hasil penelitian.
Tujuan. Menentukan perbedaan feritin serum pada penyandang talasemia β mayor dengan hipotiroid dan eutiroid.
Metode. Jenis penelitian ini adalah analitik observasional rancangan cross sectional pada penyandang talasemia β mayor di poliklinik anak Hemato-Onkologi RSUP Dr. Hasan Sadikin. Subjek diperiksakan TSH, FT4, T3 dan feritin, dibagi menjadi kelompok hipotiroid dan eutiroid, kemudian diklasifikasikan menjadi hipotiroid nyata, subklinis, sekunder dan eutiroid. Analisis menggunakan Uji Mann Whitney dan Kruskall Wallis.
Hasil. Subjek penelitian 68 anak, 38 subjek (55%) mengalami hipotiroid. Feritin serum kelompok hipotiroid 3275 ng/dL, berbanding 3648 ng/dL pada eutiroid, tidak berbeda bermakna (p=0,443). Terdapat hubungan feritin serum dengan klasifikasi hipotiroid. Feritin serum berdasarkan klasifikasi hipotiroid nyata, subklinis, sekunder dan eutiroid secara berurutan sebesar 6575, 2687, 4089, dan 3648 ng/mL (p=0,027). Analisis posthoc mendapatkan hipotiroid nyata dan subklinis berbeda bermakna.
Kesimpulan. Hasil penelitian ini menunjukkan feritin serum tidak berbeda pada kelompok hipotiroid dan eutiroid, tetapi berbeda pada hipotiroid nyata dan subklinis. Hasil penelitian mendorong dilakukan evaluasi profil tiroid secara rutin sejak dini.
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DOI: http://dx.doi.org/10.14238/sp19.3.2017.161-5
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