Infeksi Helicobacter Pylori pada Anak
Sari
Helicobacter pylori (H. pylori) berkolonisasi di dalam lambung manusia, terutama pada
anak. Infeksi H. pylori pada umumnya asimtomatis. Vacuolating cytotoxin A (Vac A) dan
cytotoxic-associated gene A (CagA) merupakan faktor virulensi yang dihubungkan dengan
manifestasi klinis yang berbeda. Kejadian infeksi ini sangat tinggi di negara berkembang
yang dihubungkan dengan kondisi sosial ekonomi dan kebersihan lingkungan. Biakan
biopsi jaringan lambung merupakan uji diagnostik baku emas terhadap infeksi H. pylori.
Uji urea napas sangat berguna untuk mengevaluasi eradikasi. Tingkat sensitivitas dan
spesifisitas pada uji serologi rendah pada masa anak-anak, sedangkan terapi eradikasi
yang direkomendasi saat ini terdiri dari proton pump inhibitors (PPI) yang dikombinasi
dengan 2 jenis antibiotik (klaritromisin, amoksisilin atau metronidazol).
Kata Kunci
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DOI: http://dx.doi.org/10.14238/sp2.2.2000.82-9
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