Hubungan Kadar Feritin Serum dengan Fungsi Kognitif Berdasarkan Pemeriksaan Status Mini-Mental (MMSE) pada Penyandang Thalassemia Anak
Sari
Latar belakang. Penyandang thalassemia yang mendapat transfusi rutin tanpa kelasi besi yang optimal dapat menyebabkan
kelebihan besi yang memicu stres oksidatif dan dapat mempercepat proses degenerasi di otak.
Tujuan. Menentukan hubungan kadar feritin serum dengan fungsi kognitif.
Metode. Penelitian analitik dengan rancangan potong lintang terhadap 95 penyandang thalassemia anak berusia di atas 10 tahun
pada bulan April sampai Mei 2015. Pemilihan subjek dilakukan secara consecutive sampling. Fungsi kognitif dinilai berdasarkan tes
mini mental state examination (MMSE). Kadar feritin serum dan faktor lain yang berhubungan dengan fungsi kognitif dianalisis
menggunakan multipel regresi.
Hasil. Subjek penelitian terdiri dari 95 anak, anak laki-laki 46 orang (48,4%) dan anak perempuan 49 orang 51,6%. Rerata(SB)
kadar feritin serum 4355,9 (2149) μg/L. Berdasarkan pemeriksaan MMSE didapatkan rerata(sb) skor 29,6 (3,9). Terdapat hubungan
antara feritin serum dan fungsi kognitif (p=0,040). Faktor lain yang berhubungan adalah pendidikan anak, pendidikan ibu dan
frekuensi transfusi.
Kesimpulan. Kadar feritin serum berhubungan dengan skor MMSE.
Kata Kunci
Teks Lengkap:
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DOI: http://dx.doi.org/10.14238/sp17.3.2015.163-8
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