Hubungan Kadar 25-Hidroksi-Vitamin D dengan HbA1c Melalui Interleukin-17 pada Anak Diabetes Melitus Tipe 1

Wahyu Wibisono, Harjoedi Adji Tjahjono


Latar belakang. Diabetes melitus tipe 1 (DMT1) merupakan penyakit autoimun yang ditandai oleh destruksi sel β pankreas dan
berhubungan dengan aktivitas Th17.
Tujuan. Mengetahui hubungan antara kadar vitamin D dengan kadar HbA1c melalui IL-17 pada anak dengan DMT1.
Metode. Desain cross-sectional dan melibatkan 20 subjek DM dan 20 kontrol sehat. Kadar vitamin D diukur dengan metode EIA (ng/
mL), kadar HbA1c diukur dengan metode kromatografi menggunakan HPLC (%), IL-17 diukur dengan metode ELISA (pg/mL).
Hasil. Kadar vitamin D pada kelompok DMT1 lebih rendah dibandingkan kelompok kontrol (p<0,05). Kadar HbA1c dan IL-17
pada kelompok DMT1 lebih tinggi dibandingkan kelompok kontrol (p<0,05). Uji korelasi pada kelompok DMT1 menunjukkan
bahwa kadar vitamin D berkorelasi positif dengan kadar IL-17 (p<0,05, R2=0,566), sedangkan kadar IL-17 berkorelasi negatif dengan
kadar HbA1c (p<0,05, R2=0,489). Namun demikian, analisis jalur menunjukkan bahwa vitamin D berhubungan tidak signifikan
dengan HbA1c melalui IL-17 (p>0,05, R2=-0,267).
Kesimpulan. Vitamin D lebih rendah pada kelompok DMT1, tetapi kadar HbA1c dan IL-17 lebih tinggi pada kelompok DMT1. Pada
kelompok DMT1, vitamin D berhubungan dengan HbA1c melalui IL-17, tetapi tidak signifikan.

Kata Kunci

diabetes melitus tipe 1; HbA1c; IL-17; vitamin D

Teks Lengkap:



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