Penggunaan Sildenafil pada Anak dengan Hipertensi Pulmonal

Sri Endah Rahayuningsih, Nono Sumarna, Armijn Firman, Dani Kurnia

Sari


Hipertensi pulmonal merupakan penyakit yang jarang akan tetapi mempunyai tingkat
mortalitas yang tinggi. Peran vasodilator, menurut beberapa penelitian dapat
meningkatkan survival rate pasien hipertensi pulmonal. Beberapa laporan kasus
memperlihatkan efektifitas sildenafil sebagai PDE5 inhibitor dalam menurunkan tekanan
rata-rata arteri pulmonal. Oleh karena itu sildenafil dapat dipertimbangkan sebagai pilihan
terapi untuk anak dengan hipertensi pulmonal


Kata Kunci


sildenafil; hipertensi pulmonal

Teks Lengkap:

PDF

Referensi


Park MK. Pulmonary hypertension. Dalam : Pediatric

cardiology for practitioners. Edisi ketiga. St Louis :

Mosby, 2002. h. 417-26.

Barst. RJ. Recent advances in the treatment of pediatric

pulmonary artery hypertension. Pediatr Clin North Am

; 46:331-41.

Nauser TD. Diagnosis and treatment of pulmonary

hypertension. American family physician 2001;

:1789-98.

Kinsella JP, Neish SR, Abman S, Wolfe R. Therapy for

pulmonary hypertension. Dalam : Garson A, Bricker

JT, Fisher DJ, Neish SR, penyunting. The science and

practice of pediatric cardiology. Edisi kedua. Baltimore:

Williams & Wilkins, 1998. h. 2345-65.

Rich S. Executive summary from the World Symposium

on Primary Pulmonary Hypertension 1998, Evian,

France, september 6-10, 1998, disponsori oleh the World

Health Organization. http://www.who.int/ncd/cvd/

pph.html.

Kulik TJ. Pulmonary hypertension. Dalam: Fyler DC,

penyunting. Nadas pediatric cardiology. Philadelphia:

Hanley & Belfus, 1992. h. 83-100.

Mehta S. Sildenafil for pulmonary arterial hypertension:

Exciting, but protection required. Chest 2003;

:989-92.

Abrams D, Neick IS, Magee AG. Sildenafil as a selective

pulmonary vasodilator in childhood primary pulmonary

hypertension. Heart 2000; 84:1-2

Michelakis E, Tymchak W, Lien D, Webster L, Hashimoto

K, Archer S. Oral sildenafil is an effective and specific

pulmonary vasodilator in patients with pulmonary arterial

hypertension. Circulation 2002; 105:2398.

Hoeper MM, Galie N, Simonneau G, Rubin LJ. New

treatment for pulmonary arterial hypertension. Am J

Respir Crit Care Med 2002; 165:1209-13.

Prasad S, Wilkinson J, Gatzoulis MA. Sildenafil in primary

pulmonary hypertension. N Engl J Med. 2000;

:1342.

Cheitlin MD, et al. Use of Sildenafil (Viagra)in patients

with cardiovascular disease. Circulation 1999; 99:167-77.

Kothari SS, Duggal B. Chronic oral sildenafil therapy

in severe pulmonary artery hypertension. Indian Heart

J 2002; 54:404-9.

Carroll WD, Dhillon R. Sildenafil as a treatment for pulmonary

hypertension. Arch Dis Child 2003; 88:827-8.

Grossman W, Braunwald E. Pulmonary hypertension.

Dalam : Braunwald E, penyunting. Heart disease. A textbook

of cardiovascular medicine. Edisi ke-4. Philadelphia

: Saunders, 1992. h. 790 - 816.

Barst RJ. Medical therapy of pulmonary hypertension.

An overview of treatment and goals. Clin Chest Med

http://www.mdconsult.com

McLaughlin VV, Rich S. Severe pulmonary hypertensio:

critical care clinics. Crit Care Clin 2001. http://

www.mdconsult.com

Kulik TJ. Pulmonary hypertension. Dalam: Pediatric

cardiac intensive care. Pine JW, penyunting. Baltimore:

Williams & Wilkins, 1998. h. 497-606.




DOI: http://dx.doi.org/10.14238/sp6.3.2004.125-8

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