Resisten Trimetoprim – Sulfametoksazol terhadap Shigellosis
Sari
Disentri merupakan salah satu penyebab kesakitan dan kematian terutama pada anak
usia di bawah 5 tahun. Penyebab tersering disentri adalah Shigella spp. World Health
Oranization (WHO) menganjurkan pemberian trimetoprim-sulfametoksazol pada diare
berdarah tanpa mengetahui penyebab. Banyak laporan mengenai resistensi trimetoprimsulfametoksazol,
sehingga perlu dicari alternatif antimikroba untuk pengobatan
shigellosis. Disamping itu, perlu pemahaman yang baik mengenai mekanisme terjadinya
resistensi.
Kata Kunci
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DOI: http://dx.doi.org/10.14238/sp7.1.2005.39-44
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