Gambaran Limfoma Burkitt di Departemen Ilmu Kesehatan Anak RSUP Cipto Mangunkusumo Jakarta

Selvi Nafianti, Endang Windiastuti, Djajadiman Gatot

Sari


Latar belakang. Limfoma Burkitt merupakan bentuk keganasan pada anak yang jarang ditemukan dibandingkan
keganasan lain. Angka kematian limfoma Burkitt sangat tinggi, namun prognosis menjadi sedikit
lebih baik karena banyak pilihan kemoterapi.
Tujuan. Mengetahui gambaran limfoma Burkitt pada anak di RSUPN Cipto Mangunkusumo Jakarta.
Metode. Penelitian dilakukan secara retrospektif dengan mengambil data dari rekam medik Divisi Hematologi-
Onkologi RSUPN Cipto Mangunkusumo periode Januari 2001 hingga Desember 2006. Semua
pasien yang datang ke Poliklinik rawat jalan dan ruang rawat inap dengan diagnosis Limfoma Burkitt
diikutsertakan dalam penelitian.
Hasil. Tercatat 7 kasus limfoma Burkitt, terdiri dari 6 laki-laki dan 1 perempuan. Usia termuda 1 tahun 5
bulan sedangkan usia tertua 14 tahun 10 bulan. Enam kasus mendapat kemoterapi, yaitu 4 kasus mendapat
kemoterapi dan operasi 2 kasus. Dari 7 kasus yang tercatat satu orang meninggal dunia.
Kesimpulan. Limfoma Burkitt adalah penyakit keganasan pada anak yang jarang ditemukan.


Kata Kunci


limfoma Burkitt; starry sky;, kemoterapi; endemik

Teks Lengkap:

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Referensi


Magrath I: Malignant non-Hodgkin’s lymphomas in

children. Dalam: Pizzo PA, Poplack DG, penyunting.

Principles and Practice of Pediatric Oncology.

Philadelphia: JB Lippincott; 4nd ed., 2002. pp 681-

Cavdar AO, Gozdasoglu S, Yavuz G. Burkitt’s lymphoma

between African and American types in Turkish children:

Clinical, viral (EBV), and molecular studies. Med Pediatr

Oncol 1993;21:36-42.

Richardson DH. Burkitt’s lymphoma clusters in a

Virginia community. Va Med 1977;104:19–21.

Tsui SHC, Wong MH, Lam WY. Burkitt’s lymphoma

presenting as mandibular swelling: Report of a case

and review of publications. Br J Oral Maxillofac Surg

;38:8-11 .

Hanazawa T, Kimura Y, Sakamaki H, Yamaguchi A,

Nagumo M, Okano T. Burkitt’s lymphoma involving

the mandible. Report of a case and review of Japanese

cases. Oral Surg Oral Med Oral Pathol 1998; 85: 216-

Halperin W, Altman R, Stemhagen A. Epidemiologic

investigation of clusters of leukemia and Hodgkin’s

diseasein Rutherford, New Jersey. J Med Soc N J

;77:267–73.

Kuttler F, Ame P, Clark H, Haughey C, Mougin C,

Cahn JY, Dang CV, Raffeld M, Fest T. c-myc box II

mutations in Burkitt’s lymphoma-derived alleles reduce

cell-transformation activity and lower response to broad

apoptotic stimuli. Oncogene 2001 Sep 20;20:6084-

Fowles JV, Olweny CL, Katongole-Mbidde E,

Lukanga-Ndawula A, Owor R. Burkitt’s lymphoma

in the appendicular

skeleton. J Bone Joint Surg – Br

;65B: 464-71

de-The G, Geser A, Day NE, Tukei PM, Williams EH, Beri

DP. Epidemiological evidence for causal relationship

between Epstein-Barr virus and Burkitt’s lymphoma from

Ugandan prospective study. Nature 978;274:756-61.

Köksal Y, Reisli, Uçar C, Avunduk M, Açıkgözo lu S,

Çalı kan Ü. A Burkitt’s lymphoma case with eyelid, renal

and pulmonary involvement. Turk J Pediatr 2006; 48:

-4.

Dilek A, Bozkaya S, Karaca I, Tokman B, Pinarli G.

Childhood Craniofacial Burkitt’s Lymphoma Presenting

as Maxillary Swelling: Report of a Case and Review of

Literature. J Dent Child 2006;73:45-50.

Heath CW. Community clusters of childhood leukemia

and lymphoma: Evidence of infection? Am J Epidemiol

;162:817–22.

Boss LP, Levine PH, Hanes RS. A cluster of young

patients with Burkitt’s lymphoma and nasopharyngeal

carcinoma in central Texas. JAMA 1985;253:2843-46.

Rao CR, Gutierrez MI, Bhatia K, Fend F, Franklin J,

Appaji L, Gallo G, O’Conor G, Lalitha N, Magrath I.

Association of Burkitt’s lymphoma with the Epstein-Barr

virus in two developing countries. Leuk Lymphoma

;39:329-37.

Fujita S, Buziba N, Kumatori A, Senba M, Yamaguchi A, Toriyama

K Early stage of Epstein-Barr virus lytic infection leading

to the “starry sky†pattern formation in endemic Burkitt

lymphoma. Arch Pathol Lab Med. 2004;128:549-52.

Miron I, Frappaz D, Brunat-Mentigny M, Combaret V,

Buclon M, Bouffet E. Initial management of advanced

Burkitt lymphoma in children: is there still a place for

surgery? Pediatr Hematol Oncol 1997;14:555-61.

Gasparini M, Rottoli L, Massimino M, Gianni MC,

Ballerini E, Ravagnani F. Curability of advanced

Burkitt’s lymphoma in children by intensive short-term

chemotherapy. Eur J Cancer 1993;29A:692-8.

Todeschini G, Tecchio C, Degani D, Meneghini V,

Marradi P, Balter R. Eighty-one percent event-free

survival

in advanced Burkitt’s lymphoma/leukemia:

no differences in outcome between pediatric and adult patients treated with the same intensive pediatric

protocol. Ann Oncol 1997;8 Suppl 1:77-81.

Revesz T, Obeid K, Mpofu C. Severe lactic acidosis and

renal involvement in a patient with relapsed Burkitt’s

lymphoma. Ped Hematol Oncol 1995;6:10-5.

Tacyildiz N, Cavdar AO, Yavuz G, Gozdasoglu S, Unal

E, Ertem U. Serum levels and differential expression of

CD44 in childhood leukemia and malignant lymphoma:

correlation with prognostic criteria and survival. Pediatr

Int 2001; 43 :354-60.




DOI: http://dx.doi.org/10.14238/sp10.1.2008.47-52

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