Pencegahan Osteoporosis dengan Suplementasi Kalsium dan Vitamin D pada Penggunaan Kortikosteroid Jangka Panjang

Ayu Setyorini, IKG Suandi, I Gst Lanang Sidiartha, Wayan Bikin Suryawan

Sari


Osteoporosis merupakan salah satu efek samping tersering pada penggunaan kortikosteroid jangka panjang, namun masih sedikit mendapat perhatian. Kortikosteroid dapat menginduksi osteoporosis dalam 6-12 bulan pertama pemakaian melalui mekanisme langsung maupun tidak langsung. Osteoporosis harus selalu dipikirkan pada anak yang menggunakan kortikosteroid jangka panjang dengan fraktur setelah trauma minimal atau tanpa trauma, nyeri tulang kronik, dan gambaran radiografi menunjukkan penipisan tulang. Efek samping ini dapat dihindari dengan pembatasan dosis kortikosteroid pada dosis minimal yang masih efektif dan mempertahankan nutrisi yang berperan dalam pembentukan tulang seperti kalsium, vitmin D, protein, dan magnesium. Suplementasi kalsium dan vitamin D memiliki efek moderat terhadap penipisan masa tulang, perlu dipertimbangkan pada penggunaan kortikosteroid jangka panjang.

Kata Kunci


glucocorticoid-induced osteoporosis; kalsium; vitamin D; metabolisme tulang

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Referensi


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DOI: http://dx.doi.org/10.14238/sp11.1.2009.32-8

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