Terapi Farmakologis Duktus Arteriosus Paten pada Bayi Prematur: Indometasin atau Ibuprofen?
Sari
Duktus arteriosus paten (DAP) merupakan kelainan yang sering dijumpai pada bayi prematur. Salah satu
upaya tata laksana DAP adalah pemberian terapi farmakologis guna memicu penutupan duktus. Sediaan
terapi farmakologis yang umumnya digunakan adalah indometasin, suatu penghambat siklooksigenase
(COX). Namun akhir-akhir ini diperkenalkan sediaan ibuprofen sebagai alternatif terapi farmakologis
yang memiliki efektifitas setara. Dilaporkan seorang bayi prematur (usia gestasi 30 minggu) dengan duktus
arteriosus paten yang berhasil di obati menggunakan ibuprofen. Tinjauan literatur menunjukkan terapi
ibuprofen pada bayi prematur dengan duktus arteriosus paten memiliki efektifitas tingkat penutupan duktus
yang setara dengan indometasin dengan efek samping serebral, gastrointestinal dan renal yang lebih rendah.
Keamanan penggunaan ibuprofen pada bayi prematur dengan hiperbilirubinemia masih belum jelas karena
efek peningkatan bilirubin yang ditimbulkannya mungkin meningkatkan risiko ensefalopati bilirubin. Di
pihak lain, sediaan ibuprofen peroral tampak memiliki efektifitas yang setara dengan sediaan intravena dan
efek samping yang terkesan lebih rendah
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DOI: http://dx.doi.org/10.14238/sp11.6.2010.401-8
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