Gambaran Uji Fungsi Paru pada Diabetes Melitus Tipe 1 Usia 8-18 Tahun
Sari
Latar belakang. Uji fungsi paru dapat membedakan kelainan paru obstruktif, restriktif atau campuran antara obstruktif dn restriktif.
Namun demikian, sampai saat ini belum ada penelitian tentang dampak DMT1 terhadap paru di Indonesia.
Tujuan. Mengetahui gambaran uji fungsi paru pada pasien DMT1 usia 8-18 tahun.
Metode. Penelitian potong lintang dilakukan di Poliklinik Endokrinologi dan Respirologi Rumah Sakit Cipto Mangunkusumo
(RSCM), serta Laboratorium Prodia pada bulan Januari 2015.Wawancara orangtua dilakukan dan data kadar HbA1c dalam rentang
satu tahun terakhir diambil dari rekam medis atau berdasarkan hasil pemeriksaan sebelumnya. Uji fungsi paru dilakukan tiga
kali dan diambil salah satu hasil yang terbaik. Kemudian darah subjek diambil untuk pemeriksaan kadar HbA1c dengan metode
cation-exchange high pressure liquod chromatography (HPLC).
Hasil. Terdapat 35 subjek, terdiri atas 68,6% perempuan. Rerata usia 14±2,7 dan median durasi DM 4 tahun (1,3-10,2). Rerata
parameter FEV1  86,8%±14%, FVC 82,7%±12% dan V 25 83,1% ± 26,2%. Median FEV1 /FVC 92,4% (77,6-100) dan V 50 91,5%
(41,1-204). Fungsi paru normal dan terganggu didapatkan 19 (54,3%) dan 16 (45,7%) subjek, terdiri atas 10 (28,6%) gangguan
restriktif, 2 (5,7%) obstruktif dan 4 (11,4%) subjek campuran. Rerata HbA1c dalam 1 tahun terakhir pada subjek dengan
gangguan restriktif 10,3%.
Kesimpulan.Nilai parameter uji fungsi paru pasien DMT1 usia 8-18 tahun masih dalam batas normal. Gangguan fungsi paru
didapatkan 16 (45,7%) subjek dengan gangguan restriksi terbanyak 10 (28,6%) subjek
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DOI: http://dx.doi.org/10.14238/sp17.4.2015.241-8
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