Hubungan Kadar Serum Metabolit Nitrit Oksida dan Gangguan Fungsi Ginjal pada Sepsis
Sari
Latar belakang. Sepsis adalah respons sistemik terhadap infeksi dengan salah satu komplikasinya berupa gagal organ ginjal. Peran nitrit oksida (NO) sebagai mediator yang terlibat dalam mekanisme gagal organ ginjal kasus sepsis masih bersifat kontroversi.
Tujuan. Mengevaluasi hubungan antara kadar serum NO dan gangguan fungsi ginjal pada sepsis anak.
Metode. Desain penelitian potong lintang secara konsekutif dilaksanakan sejak bulan Juni sampai November 2012 dengan sampel anak usia satu bulan sampai lima tahun yang didiagnosis sepsis. Pemeriksaan kadar serum kreatinin mencerminkan fungsi ginjal dan kadar serum metabolit NO (nitrat dan nitrit) mencerminkan kadar NO endogen. Uji korelasi menggunakan uji korelasi Spearman, dinyatakan bermakna apabila p<0,05. Data diolah menggunakan piranti lunak SPSS 19.00
Hasil. Diperoleh 40 subjek dengan median usia 8,5 bulan (2 sampai 70 bulan) dan 22 di antaranya anak laki-laki. Kadar metabolit NO ditemukan berhubungan dengan kadar serum kreatinin (rs=0,33; p=0,041).
Kesimpulan. Terdapat hubungan antara peningkatan kadar serum NO dan terjadinya gangguan fungsi ginjal pada anak dengan sepsis.
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DOI: http://dx.doi.org/10.14238/sp15.4.2013.259-63
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