Hubungan Kadar Serum Aminotransferase dengan Derajat Perlemakan Hati pada Remaja Obesitas

Febianne Eldrian, Yusri Dianne Jurnalis, Hirowati Ali, Hafni Bachtiar, Rozetti Rozetti

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Latar belakang. Prevalensi penyakit perlemakan hati non alkoholik (PPHNA) meningkat bersamaan dengan peningkatan obesitas pada anak dan remaja. Sebagian besar PPHNA asimtomatis sehingga penting deteksi dini terutama pada remaja obes karena progresifitas dapat meningkatkan morbiditas dan mortalitas sirosis pada dewasa muda.
Tujuan. Menganalisis hubungan kadar serum aminotransferase (aspartat aminotransferase dan alanin aminotransferase) dengan derajat perlemakan hati pada remaja obesitas.
Metode. Penelitian cross sectional pada remaja obesitas di Kota Padang dengan jumlah subyek penelitian 43 orang.
Hasil. Rerata kadar serum ALT lebih tinggi daripada rerata kadar serum AST. Tidak ada subyek pada kelompok bukan PPHNA yang mengalami peningkatan kadar serum aminotransferase. Berdasarkan pemeriksaan USG abdomen, gambaran perlemakan hati derajat I (mild), derajat II (moderate), derajat III (severe) berturut-turut 25 (64%), 8 (20,5%), dan 6 (15,2%) orang. Tidak terdapat hubungan antara kadar serum aminotransferase dengan derajat perlemakan hati pada remaja obesitas.
Kesimpulan. Rerata kadar serum aminotransferase pada kelompok PPHNA lebih tinggi daripada kelompok bukan PPHNA. Tidak terdapat hubungan antara kadar aminotransferase dengan perlemakan hati pada remaja obes. Berdasarkan pemeriksaan ultrasonografi abdomen sebagian besar perlemakan hati adalah derajat I (mild).


Kata Kunci


perlemakan hati non alkoholik; remaja; obesitas

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Referensi


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DOI: http://dx.doi.org/10.14238/sp17.5.2016.361-366

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