Profil Klinis dan Luaran Pasien Anak dengan Covid-19 yang Dirawat di Ruang Isolasi Rumah Sakit Umum Daerah Balaraja Selama Gelombang Ketiga
Sari
Latar belakang. Terdapat peningkatan kasus Covid-19 dan angka rawat inap anak selama gelombang pandemi ketiga di Indonesia, Januari sampai April 2022. Banyak hal baru muncul terkait Covid-19 pada anak, tetapi data dan penelitiannya masih terbatas.
Tujuan. Mengetahui profil klinis dan luaran pasien anak yang dirawat inap dengan Covid-19 selama gelombang ketiga.
Metode. Penelitian observasional deskriptif menggunakan data rekam medis dari pasien anak berusia 0-18 tahun terkonfirmasi Covid-19 dengan tes PCR SARS-CoV-2 di ruang isolasi Covid-19 RSUD Balaraja selama bulan Februari - April 2022.
Hasil. Terdapat 23 pasien, terbanyak (43,5%) berusia 1-5 tahun. Gejala tersering adalah demam <3 hari (78,3%), gejala respiratori (69,6%), gastrointestinal (69,6%), neurologis (52,2%). Diagnosis kerja terbanyak adalah status epileptikus dan kejang demam (34,8%), diare dan vomitus dengan dehidrasi (26,1%). Satu orang meninggal dan rerata lama rawat 6,3+4 hari. Pasien dengan CRP positif lebih banyak yang dirawat lama. Rerata leukosit dan trombosit pada pasien yang dirawat lama adalah 20.940,0+18.197,9/µL dan 477.400+230.402,5/µL.
Kesimpulan. Gejala klinis bervariasi, umumnya lebih dari satu sistem organ. Diagnosis kerja terbanyak berhubungan dengan masalah neurologis. Secara umum luaran pasien baik, pasien dengan gejala respiratori dan CRP positif lebih banyak yang dirawat lama dengan nilai leukosit dan trombosit lebih tinggi.
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Liu YC, Kuo RL, Shih SR. Covid-19: The first documented coronavirus pandemic in history. Biomed J 2020;43:328-33.
World Health Organization. Indonesia-WHO Coronavirus (Covid-19) Dashboard [internet]. 2022 [diakses 15 May 2022]. Didapat dari: https://Covid19.who.int/region/searo/country/id.
Satuan Tugas Penanganan Covid-19. Peta Sebaran. 2022 [diakses 15 Mei 2022]. Didapat dari: https://Covid19.go.id/peta-sebaran.
Marks KJ, Whitaker M, Agathis NT, dkk Hospitalization of infants and children aged 0–4 years with laboratory-confirmed Covid-19—Covid-NET, 14 States, March 2020–February 2022. Morbidity Mortality Weekly Report 2022;71:429.
Shi DS, Whitaker M, Marks KJ, dkk. Hospitalizations of children aged 5–11 years with laboratory-confirmed Covid-19—Covid-NET, 14 states, March 2020–February 2022. Morbidity Mortality Weekly Report 2022;71:574.
Sjarif DR. Prinsip asuhan nutrisi pada anak. Dalam: Sjarif DR, Lestari ED, Mexitalia M, Nasar SS, penyunting. Buku Ajar Nutrisi Pediatrik dan Penyakit Metabolik Jilid I. Badan Penerbit IDAI; 2011.h.36-48.
Unit Kerja Koordinasi Nutrisi dan Penyakit Metabolik Ikatan Dokter Anak Indonesia. Rekomendasi Ikatan Dokter Anak Indonesia : Asuhan nutrisi pediatrik (Pediatric Nutrition Care). Jakarta: IDAI; 2011.
Kementrian Kesehatan Republik Indonesia. Peraturan Menteri Kesehatan Republik Indonesia Nomor 2 Tahun 2020 Tentang Standar Antropometri Anak. Jakarta: Menteri Kesehatan Republik Indonesia; 2020.
Sockrider M, Evey LW, Grad R, Leong A, Baker J, Gettys A. Oxygen therapy for children. Am J Respir Crit Care Med 2019;199:5-6.
Soebandrio A, Kusumaningrum T, Yudhaputri FA, Oktavianthi S, Malik SG, Myint KS. Characteristics of children with confirmed SARS-CoV-2 infection in Indonesia. J Clin Virol Plus 2021;1:100027.
Widjanarko MW, Nindya M, Fernandez G, Jovito A. Comorbidities and Covid-19 severity in pediatric patients: systematic review and meta-analysis. Paediatr Indones 2022;62:51-60.
Pudjiadi AH, Putri ND, Sjakti HA, dkk. Pediatric Covid-19: report from Indonesian pediatric society data registry. Front Pediatr 2021;981. Doi: https://doi.org/10.3389/fped.2021.716898.
Parcha V, Booker KS, Kalra R, dkk. A retrospective cohort study of 12,306 pediatric Covid-19 patients in the United States. Scientific Reports 2021;11:1-0.
Singh P, Attri K, Mahto D, dkk. Clinical Profile of Covid-19 Illness in children-experience from a tertiary care hospital. Indian J Pediatr 2022;89:45-51.
Puoti MG, Rybak A, Kiparissi F, Gaynor E, Borrelli O. SARS-CoV-2 and the gastrointestinal tract in children. Front Pediatr 2021;67.
Calitri C, Fumi I, Ignaccolo MG, dkk. Gastrointestinal involvement in paediatric Covid-19 - From pathogenesis to clinical management: A comprehensive review. World J Gastroenterol 2021;27:3303 –16.
Fernandes DM, Oliveira CR, Guerguis S, dkk. Severe acute respiratory syndrome coronavirus 2 clinical and syndromes and predictors of disease severity in hospitalized children and youth. J Pediatr 2020;230:23-31.e10.
Ikatan Dokter Anak Indonesia. Panduan klinis tata laksana Covid-19 pada anak. Edisi 3. Jakarta: Ikatan Dokter Anak Indonesia; 2020.
Kurd M, Hashavya S, Benenson S, Gilboa T. Seizures as the main presenting manifestation of acute SARS-CoV-2 infection in children. Eur J Epilepsy 2021:89-93.
Hartoyo E, Ariyani R, Fitri L, Nurfahmayati T, Qotrunnada SA, Rahmiati R. Studi deskriptif dan analitik Covid-19 pada anak di Rumah Sakit Umum Daerah Ulin Banjarmasin. Sari Pediatri 2022;23:290-8.
Ludvigsson JF. Convulsions in children with Covid-19 during the Omicron wave. Acta Paediatrica 2022;111:1023–6.
Cloete J, Kruger A, Masha M, dkk. Paediatric hospitalisations due to Covid-19 during the first SARS-CoV-2 omicron (B.1.1.529) variant wave in South Africa: a multicentre observational study. Lancet Child Adolesc Health 2022;6:294-302.
Albuali WH, Alghamdi AA, Aldossary SJ, dkk. Clinical profile, risk factors and 19 : a outcomes of pediatric Covid- retrospective cohort multicentre study in Saudi Arabia. BMJ Open 2022;12e053722.
Marzano AV, Genovese G, Fabbrocini G, dkk. Varicella-like exanthem as a specific Covid-19–associated skin manifestation: Multicenter case series of 22 patients. J Am Academy Dermatol 2020;83:280-5.
Cimolai N. The complexity of co-infections in the era of Covid-19. SN Comprehensive Clin Med 2021;3:1502-14.
Wang Z, Zhao S, Tang Y, dkk. Potentially effective drugs for the treatment of Covid-19 or MIS-C in children: a systematic review. Eur J Pediatr 2022;181:2135-46.
Goldman DL, Aldrich ML, Hagmann SHF, dkk. Compassionate use of remdesivir in children with severe Covid-19. Pediatrics 2021;147:e2020047803 .
Burhan E, Susanto AD, Nasution SA, dkk. Cedera miokardium pada infeksi Covid-19. Pedoman tatalaksana Covid-19. Jakarta: Edisi ke-4. 2022. h.79–85.
Swann OV, Holden KA, Turtle L, dkk. Clinical characteristics of children and young people admitted to hospital with Covid-19 in United Kingdom: Prospective multicentre observational cohort study. The BMJ 2020;370:3249
Aguilera-Alonso D, Epalza C, Sanz-Santaeufemia FJ, dkk. Antibiotic prescribing in children hospitalized with Covid-19 and multisystem inflammatory syndrome in Spain: prevalence, trends, and associated factors. J Pediatric Infect Dis Soc 2022; 11:225-8.
Raychaudhuri D, Sarkar M, Roy A, dkk. Covid-19 and Co-infection in children: The Indian perspectives. J Trop Pediatr 2021;67:1–9.
Yock-Corrales A, Lenzi J, Ulloa-Gutiérrez R, dkk. High rates of antibiotic prescriptions in children with Covid-19 or multisystem inflammatory syndrome: A multinational experience in 990 cases from Latin America. Acta Paediatrica 2021;110:1902-10.
Lu W, Yang L, Li X, dkk. Early immune responses and prognostic factors in children with Covid-19: a single-center retrospective analysis. BMC Pediatrics 2021;21:1-11.
Dewi R, Kaswandani N, Karyanti MR, dkk. Mortality in children with positive SARS-CoV-2 polymerase chain reaction test: Lessons learned from a tertiary referral hospital in Indonesia. Int J Infect Dis.2021;107:78.
Henry BM, Benoit SW, de Oliveira MH, dkk. Laboratory abnormalities in children with mild and severe coronavirus disease 2019 (Covid-19): a pooled analysis and review. Clin Biochem 2020;81:1-8.
Graff K, Smith C, Silveira L, dkk. Risk factors for severe Covid-19 in children. Pediatr Infect Dis J.2021;40:e137-45
Samprathi M, Jayashree M. Biomarkers in Covid-19: An Up-To-Date Review. Front Pediatr 2021;8:1-12.
DOI: http://dx.doi.org/10.14238/sp24.3.2022.141-50
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