Peran Kadar Bilirubin Umbilikal sebagai Prediktor Hiperbilirubinemia pada Neonatus
Sari
Latar belakang. Kadar puncak bilirubin terjadi pada 72 hingga 96 jam setelah bayi baru lahir. Hiperbilirubinemia pada neonatus dapat berdampak serius jika tidak ditangani dengan tepat. Untuk menghindari dampak serius dari hiperbilirubinemia, dibutuhkan pemeriksaan yang dapat memprediksi hiperbilirubinemia pada neonatus.
Tujuan. Mengetahui nilai prediksi kadar bilirubin umbilikal terhadap kejadian hiperbilirubinemia pada neonatus.
Metode. Penelitian observasional analitik dengan pendekatan kohort prospektif. Pengambilan sampel dilakukan secara consecutive sampling pada bayi baru lahir di RSUD Dr. Moewardi pada bulan Januari 2021 – Juni 2021. Data dianalisis menggunakan uji chi square dan uji Mann Whitney, tingkat kemaknaan hasil uji ditentukan berdasarkan nilai p<0,05.
Hasil. Dari 30 subyek neonatus, didapatkan 10 neonatus dengan hiperbilirubinemia dan 20 neonatus tanpa hiperbilirubinemia. Kadar bilirubin umbilikal pada neonatus dengan hiperbilirubinemia (7,22+7,06 mg/dL) lebih tinggi secara signifikan dibandingkan dengan neonatus tanpa hiperbilirubinemia (3,33+1,82 mg/dL) (p=0,003). Nilai cut off bilirubin umbilikal untuk hiperbilirubinemia adalah >3,78 mg/dL dengan sensitivitas 90%, spesifisitas 80%, dan risiko relatif (RR) 11,769; (IK 95% 1,699- 81,545).
Kesimpulan. Kadar bilirubin umbilikal dapat digunakan sebagai prediktor hiperbilirubinemia dengan nilai cut off untuk hiperbilirubinemia adalah >3,78 mg/dL.
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American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 2004;114:297–316.
Han S, Yu Z, Liu L, dkk. A model for predicting significant hyperbilirubinemia in neonates from China. Pediatrics 2015;136:896–905.
Bhat JA. Pediatrics and neonatal biology open access correlation of cord blood bilirubin values with neonatal jaundice in health newborns : a prospective observational study. Pediatr Neonat biol 2018;1-6.
Jones KDJ, Grossman SE, Kumaranayakam D, Rao A, Fegan G, Aladangady N. Umbilical cord bilirubin as a predictor of neonatal jaundice: a retrospective cohort study. BMC Pediatr 2017;17:1–6.
Aktas S, Dogan C, Okmen ZH, Gulec SG. Is cord blood bilirubin level a reliable predictor for developing significant hyperbilirubinemia? Am J Perinatol 2018;36:317–21.
Castillo A, Grogan TR, Wegrzyn GH, Ly KV, Walker P, Calkins KL. Umbilical cord blood bilirubins, gestational age, and maternal race predict neonatal hyperbilirubinemia. PLoS One 2018;20:1–12.
Bijari BB, Jamali Z, Niknafs P, Norouzi E, Mosavi H, dkk. Are cord blood bilirubin values trustable to predict the forthcoming significant hyperbilirubinemia requiring treatment in healthy term newborns? Iran J Pediatr 2019;29:1-5.
Kardum D, Serdacu I, Biljan B, Santi K, Zivkovi V, dkk. Cord blood bilirubin and prediction of neonatal hyperbilirubinemia and perinatal infection in newborns at risk of hemolysis. Jornal de Pediatria 2021;97:440-4.
El Mashad GM, El Sayed HM, El Shafie WA. Cord blood albumin–bilirubin as a predictor for neonatal hyperbilirubinemia. Menoufia Med J 2019;32:1071-7.
Satrya R, Effendi SH, Gurnida DA. Correlation between cord blood bilirubin level and incidence of hyperbilirubinemia in term newborns. Paediatr Indones 2009;49:349-54.
Rajput G, Dhanawade S. Cord bilirubin as a predictor of neonatal hyper bilirubinemia in healthy term babies. Ped Rev Int J Ped Rev 2018;5:243–8.
Baskar C, Babu ASKK, Anandan H. To study the predictive value of umbilical cord bilirubin in neonatal hyperbilirubinemia. J Int Med Res 2018;5:1–5.
Zanardo V, Simbi AK, Parotto M, dkk. Umbilical cord bilirubin level and pre-discharge hyperbilirubinemia risk. J Matern Neonatal Med 2019;0:1–7.
Garg DA. Umbilical Cord Bilirubin-an Early Diagnostic Marker of Significant Neonatal Hyperbilirubinemia. J Med Sci Clin Res 2017;5:20345–9.
Bhat JA, Sheikh SA, Ara R. Correlation of cord blood bilirubin values with neonatal jaundice in healthy newborns: a prospective observational study. Arch Med Health Sci 2019;7:48-52.
Ramamoorthy K, Abilash MS. Cord blood bilirubin used as an early predictor of hyperbilirubinemia. Int J Contemp Pediatr 2018;5:1280-5.
Calkins K, Roy D, Molchan L, Bradley L, Grogan T, Elashoff D, dkk. Predictive value of cord blood bilirubin for hyperbilirubinemia in neonates at risk for maternal- fetal blood group incompatibility and hemolytic disease of the newborn. J Neonatal Perinatal Med 2015;8:243–50.
Ayd?n B, Beken S, Zenciro?lu A, Dilli D, Okumu? N. Blood eosinophil levels in newborns with severe indirect hyperbilirubinemia treated with phototherapy. Iran J Pediatr 2014;24:267-72.
Peeters B, Geerts I, Van Mullem M, Micalessi I, Saegeman V, Moerman J. Post-test probability for neonatal hyperbilirubinemia based on umbilical cord blood bilirubin, direct antiglobulin test, and ABO compatibility results. Eur J Pediatr 2016;175:651–7.
Hemmati F, Hashemi Z. Evaluation of the predictive value of umbilical cord serum bilirubin level for the development of subsequent hyperbilirubinemia in term and late-preterm neonates. Iran J Neonatol 2016;7:25–31.
Kaplan M, Algur N, Hammerman C. Onset of jaundice in glucose-6-phosphate dehydrogenase–deficient neonates. Pediatrics 2001;108:956-9.
DOI: http://dx.doi.org/10.14238/sp24.2.2022.119-26
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