Occult Infection pada Anak Setelah 10 Tahun Mendapat Imunisasi Hepatitis B
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Latar belakang. Occult hepatitis B infection (OBI) adalah suatu keadaan ditemukannya deoxyribose-nucleic acid (DNA) virus Hepatitis B (VHB) pada pemeriksaan HBsAg negatif. Mutasi pada preS2/S menyebabkan sekresi HBsAg menurun sehingga kadar HBsAg dalam serum terlalu rendah yang menyebabkan HBsAg tidak terdeteksi. Virus hepatitis B cenderung mengalami mutasi sebab tidak memiliki sistem koreksi selama replikasi karena tidak adanya 3’,5’exonuclease untuk mengkoreksi kesalahan insersi nukleotida saat transkripsi balik.
Tujuan. Mengetahui insiden occult infection setelah 10 tahun mendapat imunisasi hepatitis B.
Metode. Penelitian observasional dengan menggunakan desain cross sectional study pada anak sekolah dasar di Kota Padang dengan jumlah subjek penelitian 40 anak.
Hasil. Jenis kelamin perempuan lebih banyak daripada laki-laki dan status gizi baik lebih banyak dari status gizi kurang. Insiden occult infection ditemukan 10% pada anak setelah 10 tahun mendapat imunisasi hepatitis B. Tidak terdapat hubungan antara antiHBs dengan occult infection.
Kesimpulan. Occult infection pada anak setelah 10 tahun mendapat imunisasi hepatitis B adalah 10 %.
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Sulaiman A. Hepatitis in Indonesia. In: Nishioka K, Suzuki H, Mishiro S, penyunting. Viral hepatitis and liver diseases. Proceedings of International Symposium on Viral Hepatitis and Liver Disease:Molecules today. Tokyo: Springer Verlag;1994.h.394-6.
Chemin I, Zoulim F. Hepatitis B virus induced hepatocellular carcinoma. Cancer letters,Elsevier 2009;286:52-9.
Raimondo G. Statements from the Toarmina expert meeting on occult hepatitis B virus infection. J Hepatol 2008;49:652-7.
Osiowy C. Detection of HBsAg mutants. J Med Virol 2006;1:48-51.
Chemin I, Trepo C. Clinical impact of occult HBV infections. J Clin Virol 2005;1:15-21.
Hsia CC, Saudamore CH, Di Bisceglie AM, Tabor E. Moleculer and serological aspects of HBsAg negative hepatitis B virus infection in North America. J Med virol 2003;70:20-6.
Kiiree CF. The epidemiology and prophylaxis of hepatitis B in sub-Saharan Africa: a view from tropical and subtropical Africa Gut 1996;38:5-12.
Mu SC, Lin YM, Jow GM, Chen BF. Occult hepatitis B virus infection in hepatitis B vaccinated children in Taiwan. J Hepatol 2008;50:264-272.
Utsumi T, Yano Y. Serologic and molecular characteristics of hepatitis B virus among school children in East Java Indonesia. Am. J. Trop Med 2010;83:189-93.
Lu SN, Su WW, Yang SS. Seculer trends and geographic variations of hepatitis B virus and hepatitis C virus-associated hepatocellular carcinoma in Taiwan. Int J Cancer 2006;119:1946-52.
Chan HL, Thamson A, Martinof PM, Piratvisuth T, Cornberg M, Rossana M dkk. Hepatitis B surface antigen quantification: Why and how to use it in 2011-A core group report. J Hepatol 2011;8:311-21.
Harvat RT. Diagnostic and clinical revelance of HBV mutations. Lab Me 2011;42:488-96.
Danta M. Hepatitis B virus testing and interpreting test result. In B positive-all you wanted to know about hepatitis B: a guide for primary care providers. WJG 2006:31-9.
Krajden M, McNabb, Petric. The laboratory diagnosis of hepatitis B virus. Can J Infect Dis Med Microbiol 2005;16:65-72.
Lusida MI, Nugrahaputra VE, Soetjipto, Handajani R, Fujii MN, Sasayama M, dkk. Novel subgenotypes of hepatitis B virus genotypes C and D in Papua Indonesia. J Clin Microbiol 2008;3:2160-6.
Roznovsky L, Orsagova I, Klaudova A,Tvrdik J, Kabieszova L, Lochman I, dkk. Long term protection against hepatitis B after newborn vaccination:20-year fooow-up. Infection 2010;38:395-400.
Metodi J, Aboud S, Mpembeni R, Munubhi E. Immunity to hepatitis B vaccine in Tanzanian under 5 children. Annals Trop Pediatircs 2010;30:129-36.
Aswati L, Jurnalis YD, Sayoeti Y, Bachtiar H. Faktor-faktor yang berhubungan dengan kadar antiHbs pada anak sekolah dasar setelah 10-12 tahun imunisasi hepatitis B di Kota Padang. Sari Pediatri 2013;14:303-308.
Chang MH. Hepatitis B virus mutation in children. Indian J of Pediatrics 2006;73:803-807.
Raimondo G, Caccamo G, Filomia R, Pollicino. Occult HBV infection. Semin Immunopathol 2013;35:39-52.
Mulrooney CPM, Michalak TI. Persistent occult hepatitis B virus infection experimental finding and critical implications. World J Gastroenterol 2013;13:5682-6.
Liu CJ, Lo SC, Kao JH, Tseng PT, Lai MY, Ni YH. Transmission of occult hepatitis B virus by transfusion to adult and pediatric recipients in Taiwan. J of Hepatology;Elsevier 2006;44:39-46.
Minuk GY, Sun DF, Uhanova J, Zhang M, Caouette S, Nicolle LE, dkk. Occult hepatitis B virus infection in North American community based population. J Hepatol 2005;42:480-5.
Lachenbruch PA, Yu MY. Quantification of hepatitis B virus genomes and infectivity in human serum samples. Transfusion 2006;46:1829-35.
Samal J, Kandpal M, Vivekanandan P. Moleculer Mechanisms Underlying Occult Hepatitis B Virus Infection. Clin Microbiol Rev 2012;25:142-63.
Romero M, Madejon A, Rodriguez CF, Samaniego JG. Clinical significance of occult hepatitis B virus infection. World J Gastroenterol 2011;17:1549-52.
Fallahian F, Zamani F. Hepatitis B vaccine: Immunity, efficacy and types. Shiraz E Med J 2010;11:39-54.
De Maddalena C, Soriano V. High level of genetic heterogeneity in S dan P genes og genotype D hepatitis virus. Virology 2007;365:113-24.
Pennie RA, Kang CY. High prevalence of occult hepatitis B among immigrant students in Canada: A case for universal immunization of young adult. Can J Infect Dis 1993;4:105-7.
Avellon A, Echevarria JM. Frequency of hepatitis B virus a determinant variant in unselected Spanish chronic carriers. J Med Virol 2006;78:24-36.
Whittle H, Jaffar S, Wansbrough M, Mendy M, Dumpis Ud. Observational study o vaccine efficacy 14 years after trial of hepatitis B vaccination in Gambian children. Br Med J 2002;325:569-74.
Damme P, Moiseeva A, Marichev ID. Five years follow-up following two or three doses of a hepatitis B vaccine in adolescents aged 11-15 years: a randomised controlled study BMC Infect Dis 2010;10:1-8.
McMahon B, Bruden D, Petersen K, dkk. Antibody level and protection after hepatitis B vaccination : results of a 15-year follow-up. Ann Intern Med 2005;142:333-41.
Hammitt LL, Hennessy TW, Fiore AE, Zanis C, Hummel KB, Dunaway E, dkk. Hepatitis B immunity in children vaccinated with recombinant hepatitis B vaccine beginning at birth: a follow-up study at 15 years. Vaccine 2007;25:6958-64.
DOI: http://dx.doi.org/10.14238/sp17.5.2016.343-348
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