Perbandingan Kadar Vitamin D [25 Hidroksivitamin D] Pada Anak Sakit Kritis dan Nonkritis
Sari
Latar belakang. Vitamin D berperan dalam fungsi pertahanan tubuh sehingga defisiensi vitamin D berhubungan dengan derajat keparahan penyakit.
Tujuan. Membandingkan kadar vitamin D pada anak sakit kritis dan nonkritis.
Metode. Penelitian potong-lintang dengan subjek terdiri atas 25 anak sakit kritis dan 25 anak sakit nonkritis. Kadar vitamin D dianalisis dengan Uji Mann Whitney, Uji Kolmogorov-Smirnov, dan Uji Korelasi Spearman. Kemaknaan dinyatakan pada p <0,05.
Hasil. Kadar vitamin D serum rerata pada kelompok kritis dan non kritis masing-masing 11,46 ng/mL dan 25,98 ng/mL (p<0,001). Pada kelompok kritis ditemukan 22/25 subjek mengalami defisiensi dan 3/25 insufisiensi. Pada kelompok nonkritis ditemukan 6/25 subjek mengalami defisiensi, 7/25 insufisiensi, dan 12/25 pasien dengan kadar normal (p<0,001). Pada uji korelasi didapatkan koefisien korelasi (r) = -0,624 (p<0,001).
Kesimpulan. Kadar vitamin D serum rerata pada sakit kritis lebih rendah daripada nonkritis dan terdapat korelasi kuat antara sakit kritis dan vitamin D rendah
Kata Kunci
Referensi
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DOI: http://dx.doi.org/10.14238/sp16.6.2015.434-40
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