Faktor Risiko Hiperkoagulasi pada Thalassemia Anak

Ridha Kurnia Tejasari, Lelani Reniarti, Sjarif Hidajat Effendi

Sari


Latar belakang. Hiperkoagulasi merupakan salah satu komplikasi thalassemia yang telah terjadi sebelum
manifestasi klinis ditemukan pada thalassemia anak. Sampai saat ini belum pernah ada penelitian khusus
mengenai faktor risiko hiperkoagulasi pada thalassemia anak.
Tujuan. Menentukan faktor risiko hiperkoagulasi pada thalassemia anak.
Metode. Desain penelitian potong lintang dilakukan sejak bulan Maret hingga April 2014 terhadap 87 subjek
di Poliklinik Thalassemia Anak RSHS Bandung. Hiperkoagulasi diketahui berdasarkan tromboelastografi
(TEG), apabila ditemukan minimal 2 dari 4 parameter terpenuhi dengan atau tanpa nilai CI lebih dari 3.
Analisis statistik faktor risiko dengan uji chi-square/Fisher dan regresi logistik.
Hasil. Prevalensi hiperkoagulasi thalassemia anak di RSHS Bandung 70% (61 subjek). Usia termuda
hiperkoagulasi positif adalah 5 tahun. Faktor risiko hiperkoagulasi thalassemia anak yang bermakna adalah
peningkatan jumlah trombosit (p=0,002; RP1,08; IK95%:1,003−1,013), sedangkan variabel lainnya
tidak berhubungan. Pasien pascasplenektomi sejumlah 9 subjek dengan kadar trombosit >500.000 mm3.
Hiperkoagulasi positif dapat memiliki jumlah trombosit yang meningkat dan/atau gangguan fungsi trombosit
berdasarkan TEG.
Kesimpulan. Peningkatan jumlah trombosit merupakan faktor risiko hiperkoagulasi thalassemia anak di
RSHS Bandung


Kata Kunci


anak; faktor risiko; hiperkoagulasi; thalassemia; tromboelastografi (TEG)

Teks Lengkap:

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Referensi


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DOI: http://dx.doi.org/10.14238/sp16.6.2015.427-33

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