Korelasi Kadar Feritin dengan Profil Lipid pada Penyandang Talasemia Beta Mayor Anak
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Latar belakang. Talasemia beta mayor merupakan penyakit genetik dengan gangguan sintesis rantai globin yang menimbulkan eritopoiesis tidak efektif sehingga membutuhkan transfusi darah rutin. Terapi tersebut menyebabkan kelebihan besi di berbagai organ termasuk di hati dan pankreas yang memengaruhi enzim hepatik lipase yang mengatur regulasi metabolisme lipid.
Tujuan. Mengetahui korelasi kadar feritin dengan profil lipid pada penyandang talasemia beta mayor anak.
Metode. Penelitian observasional analitik dengan rancang potong lintang, dilaksanakan November - Desember 2018. Subjek adalah penyandang talasemia beta mayor di Rumah Sakit Hasan Sadikin, secara consecutive sampling. Dilakukan pemeriksaan serum feritin, trigliserida, kolesterol total, low density lipoprotein (LDL), dan high density lipoprotein (HDL). Uji statistik menggunakan uji korelasi rank Spearman dengan kemaknaan nilai p<0,05.
Hasil. Terdapat sampel sebanyak 40 penderita talasemia beta mayor, 20 perempuan dan 20 laki-laki. Rerata serum feritin 4328,2 mcg/L, kolesterol total 93,78 mg/dl, HDL 20,65 mg/dl, LDL 52,95 mg/dl, dan trigliserida 154,95mg/dl. Tidak didapatkan korelasi antara feritin dengan kolesterol total dan LDL (p>0,05). Terdapat korelasi antara kadar feritin terhadap kadar serum kolesterol HDL dan trigliserida (r= -0,349, p=0,029 dan r= 0,460, p=0,003).
Kesimpulan. Terdapat korelasi negatif antara kadar feritin terhadap kolesterol HDL dan korelasi positif terhadap trigliserida. Semakin tinggi feritin, semakin rendah HDL, semakin tinggi trigliserida.
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DOI: http://dx.doi.org/10.14238/sp21.3.2019.189-94
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