Hubungan antara Profil Lipid, Ketebalan Tunika Intima Media Arteri Karotis dan Masa Ventrikel Kiri pada Remaja Obes
Sari
Latar belakang. Obesitas pada anak merupakan salah satu faktor risiko penyakit kardiovaskular. Belum
diketahui apakah profil lipid pada anak obes akan berpengaruh terhadap ketebalan tunika intima media
(KIM) arteri karotis dan selanjutnya menyebabkan perubahan pada masa ventrikel kiri (MVK).
Tujuan. Mengetahui hubungan antara profil lipid, ketebalan tunika intima media arteri karotis dan massa
ventrikel kiri pada remaja obes.
Metode. Dilakukan penelitian observasional analitik dengan metode potong lintang terhadap 37 remaja
obes berusia 13-18 tahun dari bulan November 2013- Februari 2014. Kriteria eksklusi adalah obesitas
dengan penyakit penyerta dan obesitas endogen. Pemeriksaan profil lipid yaitu kolesterol total, LDL, HDL
dan trigliserida. Penilaian KIM arteri karotis dan MVK dilakukan dengan ekokardiografi. Analisis deskriptif
untuk menganalisis karakteristik dan analisis korelasi menggunakan uji Pearson.
Hasil. Kadar rerata kolesterol total 186,45 mg/dL, LDL 128,83 mg/dL, HDL 45,83 mg/dL, trigliserida
110,75 mg/dL, KIM 0,67 mm, dan MVK 393 gr. Terdapat hubungan bermakna antara kadar HDL dengan
KIM arteri karotis (r= -0,338, p=0,02). Tidak didapatkan hubungan antara kadar kolesterol total, LDL dan
trigliserida dengan KIM (secara berturut-turut r= 0,079, p=0,320; r= 0,085, p=0,309; r=0,116, p=0,247),
dan tidak didapatkan hubungan antara KIM dan MVK (r=0,109, p=0,261).
Kesimpulan. Semakin tinggi kadar HDL, semakin rendah ketebalan tunika intima media arteri karotis.
Ketebalan tunika intima-media arteri karotis tidak berhubungan dengan masa ventrikel kiri.
Kata Kunci
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DOI: http://dx.doi.org/10.14238/sp16.5.2015.319-24
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