Immune Thrombocytopenic Purpura
Sari
Immune thrombocytopenic purpura (ITP) telah mengalami perubahan definisi dan klasifikasi. Definisi ITP sebagai jumlah trombosit <100.000/uL dengan klasifikasi new diagnosed ITP, ITP persisten, dan ITP kronik. Disregulasi imun ITP menyebabkan menurunnya jumlah megakariosit di sumsum tulang dan trombosit di darah tepi. Diagnosis ditegakkan secara klinis dan pemeriksaan penunjang. Berbagai penelitian telah menunjukkan banyak perubahan pada tata laksana ITP. Bila tidak ada perdarahan ataupun perdarahan ringan, kasus ITP dapat ditatalaksana hanya dengan observasi. Namun demikian, dokter tetap harus dipertimbangkan faktor sosial dalam menentukan pilihan terapi seperti kecemasan orang tua, akivitas anak, dan jarak ke pusat kesehatan. Terapi IVIG dan kortikosteroid tetap menjadi pilihan pertama dalam tata laksana ITP bila terjadi perdarahan berat ataupun mengancam jiwa.
Kata Kunci
Teks Lengkap:
PDFReferensi
Neunert C, Lim W, Crowther M, Cohen A, Solberg Jr L, Crowther MA. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood 2011;117: 4190-207.
Breakey VR, Blanchette VS. Childhood immune thrombocytopenia: a changing therapeutic landscape. Semin Thromb Hemost 2011;37:745-55.
Neunert CE. Current management of immune thrombocytopenia. Hematology 2013;2013:276-82.
Neunert CE, Buchanan GR, Imbach P, dkk. Intercontinental Childhood ITP study group registry II Participants. Severe hemorrhage in children with newly diagnosed immune thrombocytopenic purpura. Blood
;112:4003-8.
Yohmi E, Windiastuti E, Gatot D. Perjalanan penyakit purpura trombositopenik imun perjalanan penyakit purpura trombositopenik imun. Sari Pediatri 2007;8:310-5.
Witmer CM, Lambert MP, O’Brien SH, Neunert C. Multicenter cohort study comparing U.S management of inpatient pediatric immune thrombocytopenia to current treatment guidelines. Pediatr Blood Cancer 2016;63:1227-31.
Tarantino MD, Danese M, Klaassen RJ, Duryea J, Eisen M, Bussel J. Hospitalizations in pediatric patients with immune thrombocytopenia in the United States. Platelets 2016;27:472-8.
McGuin C, Bussel JB. Disorders of platelet. Dalam: Lanzkowsky’s Manual of Pediatric Hematology and Oncology. 6th ed. Lanzkowsky P, Lipton JM, Fish JD, penyunting. Elsevier; Oxford;2016.h.254-61.
Provan D, Stasi R, Newland AC, Blanchette VS, Bolton-Maggs P, Bussel JB, dkk. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 2010;115:168-86.
Cuker A, Cines DB, Neunert CE. Controversies in the treatment of immune thrombocytopenia. Curr Opin Hematol 2016, 23:479-485.
Neunert CE. Management of newly diagnosed immune thrombocytopenia: can we change outcome? Hematology Am Soc Hematol Educ Program 2017;2017:400-5.
De Mattia D, Del Principe D, Del Vecchio GC, Jankovic M, Arrghini A, Giordano P, dkk. Acute childhood idiopathic thrombocytopenic purpura: AIEOP consensus guidelines for diagnosis and treatment. Associazione Italiana di Ematologica e Oncologia Pediatrica. Haematologica 2000;85:420-4.
Sruamsiri R, Dilokthornsakul P, Pratoomsoot C, Chaiyakunapruk N. A cost-effectiveness study of intravenous immunoglobulin in childhood idiopathic thrombocytopenia purpura patients with life-treatening bleeding. Pharmacoeconomic. 2014;32:801-13.
Choi HS, Ji MH, Kim SJ, Ahn HS. Platelet count recovery after intravenous immunoglobulin predicts a favorable outcome in children with immune thrombocytopenia. Blood Res 2016;51:95-101.
Chotsampancharoen T, Sripornsawan P, Duangchoo S, Wongchanchailert M, McNeil E. Predictive factors for resolution of childhood immune thrombocytopenia: Experience from a single tertiary center in Thailand. Pediatr Blood Cancer 2017;64:128-34.
Shim YJ, Kim UH, Suh JK, Lee KS. Natural course of childhood chronic immune thrombocytopenia using the revised terminology and definitions of the international working group: a single center experience. Blood Res 2014;49:187-91.
Evim MS, Baytan G, Güneş AM. Childhood immune thrombocytopenia: Long-term follow-up data evaluated by the criteria of the International Working Grooup on Immune Thrombocytopenia Purpura. Turk J Haematol 2014;31:32-9.
Rodehiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, dkk. Standarization of terminology, definitions and outcome criteria ini immune thrombocytopenic purpura of adults and children: report from an international working group. Blood 2009;113:2386-93.
DOI: http://dx.doi.org/10.14238/sp20.1.2018.58-64
Refbacks
- Saat ini tidak ada refbacks.
##submission.copyrightStatement##
##submission.license.cc.by-nc-sa4.footer##
Email: editorial [at] saripediatri.org
Sari Pediatri diterbitkan oleh Badan Penerbit Ikatan Dokter Anak Indonesia
Ciptaan disebarluaskan di bawah Lisensi Creative Commons Atribusi-NonKomersial-BerbagiSerupa 4.0 Internasional.