Red-Cell Distribution Width (RDW) dan Mean Platelet Volume (MPV) sebagai Biomarker Keparahan Pneumonia Anak
Sari
Latar belakang. Pneumonia masih menjadi salah satu penyebab utama morbiditas dan mortalitas anak balita di seluruh dunia. Red-cell distribution width (RDW) dan mean platelet volume (MPV) adalah dua parameter dalam pemeriksaan darah lengkap yang sederhana, murah, dan tersedia hampir di seluruh rumah sakit di Indonesia. Penggunaannya sebagai biomarker keparahan pneumonia dapat menjadi salah satu upaya untuk menurunkan morbiditas dan mortalitas akibat pneumonia.
Tujuan. Menganalisis hubungan antara nilai RDW dan MPV dengan derajat keparahan pneumonia anak.
Metode. Penelitian cross-sectional dilaksanakan pada Juni-November 2017 di RSUD Nganjuk, melibatkan 30 anak berusia 2-59 bulan dengan pneumonia. Nilai RDW dan MPV dihubungkan dengan klasifikasi diagnosis, derajat keparahan yang diukur menggunakan skor RISC (respiratory index of severity in children) dan PRESS (pediatric respiratory severity score), dan hasil terapi pneumonia.
Hasil. Terdapat perbedaan bermakna pada nilai RDW antara subjek dengan pneumonia dan pneumonia berat (t28=-1,721, p=0,096). Nilai RDW antara kelompok dengan nilai PRESS rendah, sedang, dan tinggi juga berbeda bermakna (F(2,27)=4,083, p=0,028). Nilai RDW berhubungan bermakna kuat dengan klasifikasi diagnosis pneumonia (x(1)=0,530, p=0,004), dan berhubungan bermakna moderate dengan skor RISC (rs=0,369, p=0,023), serta skor PRESS (rs=0,318, p=0,043).
Kesimpulan. Nilai RDW berhubungan dengan klasifikasi diagnosis pneumonia, skor RISC dan skor PRESS.
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DOI: http://dx.doi.org/10.14238/sp19.6.2018.335-41
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