Hubungan Kadar Docosahexaenoic Acid Terhadap Perlemakan Hati Non Alkoholik Remaja Obesitas
Sari
Latar belakang. Penyakit hati berlemak non alkohol (NAFLD) adalah penyakit yang ditandai dengan timbunan lemak yang signifikan di hepatosit dari parenkim hati yang menyebabkan kerusakan hati berupa peradangan. Prevalensi NAFLD meningkat seiring dengan meningkatnya obesitas pada anak dan remaja. Docosahexaenoic acid (DHA) merupakan salah satu pengobatan farmakologis untuk NAFLD dan belum ada data terbaru yang spesifik untuk pengukuran DHA pada anak NAFLD.
Tujuan. Menganalisis hubungan DHA dengan NAFLD , dan mengukur nilai DHA setiap derajat NAFLD.
Metode. Lima puluh delapan remaja obesitas (31 laki-laki, 27 perempuan), berusia 14-18 tahun yang terpantau di kota Padang, sejak Juni – Juli 2017. Penelitian ini bersifat observasional cross sectional.
Hasil. Tidak ada perbedaan jenis kelamin yang diamati pada NAFLD. Indeks massa tubuh pada kelompok NAFLD lebih tinggi daripada non-NAFLD 30,30±4,21kg/m2 vs 28,70±2,65 kg/m2. Pengukuran derajat penyakit perlemakan hati non alkohol dengan hasil USG masing-masing derajat ringan, sedang dan berat adalah 12(37,5%), 15(46,8%) dan 5(15,6%). Selain itu, kandungan DHA memiliki perbedaan yang signifikan pada masing-masing kelompok, penyakit perlemakan hati non-alkohol vs non-NAFLD 40,46±19,23 menjadi 89,26±41,21µg/ml dengan p<0,0001.
Kesimpulan. Nilai DHA signifikan lebih rendah pada kelompok penyakit hati berlemak non alkohol yang dikonversi dengan non-NAFLD. Manajemen diet dengan DHA tinggi penting untuk mencegah dan mengelola obesitas dengan lebih baik.
Kata Kunci
Teks Lengkap:
PDFReferensi
Schiff L, Schiff ER. Fatty liver. Biochem Clin Aspects 1995;825-55.
Edmison J, McCullough AJ. Pathogenesis of Non-alcoholic. Steatohepatitis: human data. Clin Liver Dis 2007;11:75–104.
Minno MN, Russolillo A, Lupoli R, Ambrosino P, dkk. Omega-3 Fatty Acids for the treatment of non-alcholic fatty liver disease. World J Gastroenterol 2012;18:5839-47.
McCarthy EM, Rinella ME. The Role of Diet and Nutrient Compositionin Non alcoholic Fatty Liver Disease. J Acad Nutr Dietet 2012:401-9.
Dowman JK, Tomlinson JW, Newsome PN. pathogenesis of non-alcoholic fatty liver disease. Q J Med 2009;103:71-83.
Vos MB, McClain CJ. Nutrition and nonalcoholic fatty liver disease in children. Current Gastroenterol Reports 2008;10:308-15.
Janczyk W, Socha P, Lebensztejn D, dkk. Omega-3 fatty acids for treatment of non-alcoholic fatty liver disease: design and rationale of randomized controlled trial. BMC Pediatrics 2013;13:1-11.
Amarapurkar D. NAFLD and NASH Asian perspective. Trop Gastroenterol 2011:23-6.
Chalasani N, Younossi Z, Lavine JE, , dkk. The diagnosis and management of non-alcoholic fatty liver disease practice guideline by the American Association for the Study of Liver Diseases American College of Gastroenterology, and The American Gastroenterological Association. Hepatology 2012;55:2005-23.
Tan H-H, Chang P-E. Non-alcoholic Fatty Liver Disease. In: Department of Gastroenterology and Hepatology SGH, Singapore. 2010;19:36-50.
Vos MB, McClain CJ. Nutrition and nonalcoholic fatty liver disease in children. Curr Gastroenterol Rep 2008;10:308-15
Capanni, Calella, Biagini MR, S. Genise, L. Raimondi. Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease:a pilot study. Alimentary Pharmacol Therapeut 2006;23:1143-51.
Nobili V, Bedogni G, alisi A, dkk. Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease. BMJ. 2011: 350-3.
Surette ME. The science behind dietary omega-3 fatty acids. CMAJ 2008;178:177-9.
Chan DFY, Li A, Chu WCW, dkk. Hepatic steatosis in obese Chinese children. International J Obes 2004;28:1257-62.
Saki F, Karamizadeh Z. Metabolic syndrome, insulin resistence and fatty liver in ibese Iranian children. Iran Red Crescent Med J 2014;16:1-5.
Febianne E, Yusri DJ, Hirowati A, Hafni B, Rozetti. Hubungan kadar serum aminotransferase dengan derajat perlemakan hati pada remaja obesitas di kota Padang [Tesis] Padang: Fakultas Kedokteran Universitas Andalas,2015.
Zhang X, Wan Y, Zhang S, dkk. Non Akcoholic fatty liver disease prevalence in urban school aged children and adolescents from the Yangtze River delta region: a cross sectional study. Asia Pac J Clin Nutr 2015;24:281-8.
Catherine EC, Jean AW, Rebecca LC, , dkk. Natural history of NAFLD diagnosed in childhood: A single-center study. Children 2017;4:1-11.
Collins JJ. Omega-3 Essential Fatty Acids. Nutri News 2010; 9:1-8.
Silvia S, Elvira V, Michela S, dkk. Plasma long-chain fatty acids and the degree of obesity in Italian children.Acta Paed 2006;95:964-9.
Emiko S, Tommo O, Yuriko A, dkk. Docosahexaenoic acid content in plasma phospholipids and desaturase indices in obese children. J Atheroscler Thromb 2011;18:345-50.
Araya J, Rodrigo R, Videla LA. Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin Sci (Lond) 2004;106:635–43.
Mager DR, Patterson C, So S. Dietary and physical activity patterns in children with fatty liver. Eur J Clin Nutr 2010;64:628–35.
Kleiner DE, Brunt EM. Nonalcoholic fatty liver disease: pathologic patterns and biopsy evaluation in clinical research. Semin Liver Dis 2012;32:3–13.
Garaulet M, Pe´rez-Llamas F, Pe´rez- Ayala M, dkk. Sitespecific differences in the fatty acid composition of abdominal adipose tissue in an obese population from a Mediterranean area: relation with dietary fatty acids, plasma lipid profile, serum insulin, and central obesity. Am J Clin Nutr 2001;74: 585–91.
Shichun D, Jie J, Wenjun F, Qing S. Does fish oil have an anti-obesity effect in overweight/obese adult? A meta-analysis of randomized controlled Trials. Plos One 2015;10:1-20.
DOI: http://dx.doi.org/10.14238/sp23.2.2021.82-7
Refbacks
- Saat ini tidak ada refbacks.
##submission.copyrightStatement##
##submission.license.cc.by-nc-sa4.footer##
Email: editorial [at] saripediatri.org
Sari Pediatri diterbitkan oleh Badan Penerbit Ikatan Dokter Anak Indonesia
Ciptaan disebarluaskan di bawah Lisensi Creative Commons Atribusi-NonKomersial-BerbagiSerupa 4.0 Internasional.