Hubungan Jumlah Koloni Escherichia Coli dengan Derajat Dehidrasi pada Diare Akut
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Latar belakang. Escherichia coli (E. coli) penyebab kedua terbanyak diare setelah rotavirus. Diare E. coli sering disertai dengan dehidrasi yang berhubungan dengan morbiditas dan mortalitas anak.
Tujuan. Mengetahui peran jumlah koloni E. coli terhadap beratnya derajat dehidrasi diare akut.
Metode. Penelitian potong lintang dilakukan di RSUP Manado. Subyek umur 7 bulan-13 tahun dengan diare akut, dinilai derajat dehidrasi, dilakukan kultur tinja dan hitung jumlah koloni. Perbandingan jumlah koloni dan derajat dehidrasi dilakukan uji korelasi Gamma (p<0,05).
Hasil. Terdapat 50% Escherichia coli dari 50 anak diare akut. Dehidrasi berat (2/25 anak), dehidrasi ringan sedang (13/25 anak) jumlah koloni >105 CFU dan tanpa dehidrasi (10/25 anak) jumlah koloni <105 CFU. Analisis korelasi Gamma menyatakan hubungan bermakna jumlah koloni dengan derajat dehidrasi (rG=0,870, nilai p=0,008).
Kesimpulan. Jumlah koloni Escherichia coli berperan terhadap derajat dehidrasi diare akut.
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World Health Organization. The world health report 2003. Geneva :WHO; 2003.
Departemen kesehatan RI. Kepmenkes RI No. 1216/Menkes/ SK/XI/2001 Tentang pedoman pemberantasan penyakit diare. Jakarta : Ditjen PP & PL, Departemen Kesehatan RI; 2007.
Departemen Kesehatan RI. Riset kesehatan dasar tahun 2007. Jakarta: Departemen Kesehatan RI; 2007.
Web A, Starr M. Acute gastroenteritis in children. Aust Fam Physician 2005;34:227-31.
Farthing M, Salam MA, Lindberg G, Dite P. Acute Diarrhea in Adults and Children: A global perspective. World Gastroenterology Organisation Global Guidelines. J Clin Gastroenterol 2013;47:12-20.
Ifeanyi CIC, Ikeneche NF, Bassey BE, Gallas N, Aissa RB, Boudabous A. Diarrhegenic Escherichia coli pathotypes isolated from children with diarrhea in the Federal Capital Territory Abuja Nigeria. J Infect Dev Ctries 2015;9:165-74.
Barletta F, Ochoa TJ, Mercado E, dkk. Quantitative real-time polymerase chain reaction for enteropathogenic Escherichia coli: a tool for investigation of asymptomatic versus symptomatic infections. CID 2011;53:1223-9.
Bryce J, Boschi-pinto C, Shibuya K, Black RE. WHO estimates of the causes of death in children. Lancet 2005;365:1147-52.
Podewils LJ, Mintz ED, Nataro JP, Parashar UD. Acute infectious diarrhea among children in developing countries. J Spid 2004;5:155-65.
Kaper JB, Nataro JP, Mobley HLT. Pathogenic Escherichia coli. Nat Rev Microbiol 2004;2:123-41.
Croxen MA, Finlay BB. Molecular mechanisms of Escherichia coli pathogenicity. Nat Rev 2010;8:26-38.
Cheng AC, McDonald JR, Thielman NM. Infectious diarrhea in developed and developing countries. J Clin Gastroenterol 2005;39:757-73.
Orlandi PP, Magalhaes GF, Matos NB, Silva T, Penatti M, Nogueira PA, dkk. Etiology of diarrheal infection in children of Porto Velho (Rondonia, Western Amazon region, Brazil). Brazilian J Med Bio Res 2006;39:507-17.
Haque R, Mondal D, Kirkpatrick BD, Akther S, Farr BM, Sack
RB, dkk. Epidemiologic and clinical characteristics of acute diarrhea with emphasis on entamoeba hystolitica infections in preschool children in an urban slum of Dhaka, Bangladesh. J Trop Med Hyg 2003;69:398-405.
Robin-Browne RM, Levine MM. Laboratory diagnostic challenges in case/control studies of diarrhea in developing countries. CID 2012;55:312-6.
Lindsay B, Ochieng JB, Ikumapayi UN, dkk. Quantitative PCR for detection of Shigella improves ascertainment of shigella burden in children with moderate to severe diarrhea in low income countries. J Clin Microbiol 2013;51:1740-6.
Patzi-Vargas S, Zaidi MB, Perez-Martinez I, dkk. Diarrhegenic Escherichia coli carrying supplementary virulence genes are an important cause of moderate to severe diarrhoeal disease in Mexico. Plos Negl Trop Dis 2015;9:1-18.
Fuchs SC, Victora CG. Risk and prognostic factors for diarrheal disease in Brazilian infants: a special case-control design application. Cad Saude Publica 2002;18:773-82.
Zodpey SP, Deshpande SG, Ughade SN, Hinge AV, Shrikhande SN. Risk factors for development of dehydration in children aged under five who have acute watery diarrhea: a case-control study. Pub Health 1998;112:233-6.
DOI: http://dx.doi.org/10.14238/sp19.2.2017.81-5
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