Hubungan antara Nilai Red Cell Distribution Width dan Fungsi Ventrikel Kiri pada Anak dengan Penyakit Jantung Bawaan Asianotik

Achmad Yudha Aditya Pratama, Sri Lilijanti Widjaja, Harsono Salimo

Sari


Latar belakang. Abnormalitas fungsi sistolik dan diastolik dari ventrikel kanan dan kiri banyak ditemukan pada pasien dengan PJB asianotik. Di Indonesia, fasilitas untuk menilai fungsi ventrikel kiri berupa ekokardiografi tidak selalu tersedia di rumah sakit perifer sehingga diperlukan penanda lain sebagai alternatif, di antaranya, red cell distribution width (RDW).
Tujuan. Menganalisis hubungan nilai RDW dan fungsi ventrikel kiri (ejeksi fraksi, fraksi pemendekan dan rasio E/A) pada anak dengan PJB asianotik di RSUD Dr. Moewardi Surakarta.
Metode. Penelitian observasional analitik dengan desain cross sectional, subjek 33 anak PJB asianotik. Hubungan antara kadar RDW dan parameter fungsi ventrikel kiri dianalisis menggunakan uji korelasi Spearman.
Hasil. Di antara 33 subjek terdapat 17 laki-laki (51,5%). Didapatkan jenis PJB asianotik VSD (ventricle septal defect) 10 pasien (30,3%), ASD (atrial septal defect) 15 pasien (45,5%) dan PDA (patent ductus arteriosus) 8 pasien (24,2%). RDW berkorelasi signifikan dengan rasio E/A pada PJB asianotik secara keseluruhan (r -0,342; p=0,026). Pada VSD dan PDA, RDW tidak berkorelasi dengan parameter fungsi ventrikel kiri apapun. Namun pada ASD, RDW berkorelasi signifikan dengan ejeksi fraksi (r -0,491; p=0,032).
Kesimpulan. Didapatkan hubungan antara RDW dengan parameter fungsi ventrikel kiri, terutama rasio E/A pada pasien PJB asianotik. Selain itu, juga terdapat hubungan antara RDW dengan ejeksi fraksi pada pasien ASD.


Kata Kunci


Red cell distribution width, fungsi ventrikel kiri, PJB asianotik

Teks Lengkap:

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Referensi


Hariyanto D. Profil penyakit jantung bawaan di instalasi rawat inap anak RSUP Dr. M. Djamil Padang Januari 2008-Februari 2011. Sari Pediatri 2012;14:152-7.

Allen HD, Franklin WH, Fontana ME. Congenital heart disease : untreated and operated. Dalam: Allen HD, Driscoll DJ, Shaddy RE, Feltes TF, penyunting. Moss and Adams’ heart disease in infants, children and adolescents including the fetus and young adult. Edisi ke-8. Philadelphia: Lippincott Williams and Wilkins; 2012.h.657-64.

Kementerian Kesehatan Republik Indonesia. Profil kesehatan Indonesia tahun 2014. Jakarta: Kemkes; 2015.

Massin MM, Astadicko I, Dessy H. Epidemiology of heart failure in a tertiary pediatric center. Clin Cardiol 2008;31:388-91.

Hunt SA, Abraham WT, Chin MH, Feldman AM. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult. A report of the American College of Cardiology/American Heart Association Task Force on practical guidelines. Diakses pada 30 Juni 2016. Didaat dari: www.accorg/qualityandscience/clinical/topic/topic.htm.

van Kimmenade RR, Mohammed AA, Uthamalingam S, van der Meer P, Felker GM, Januzzi JL Jr. Red blood cell distribution width and 1-year mortality in acute heart failure. Eur J Heart Fail 2010;12:129–36.

Thakur V, Fouron JC, Mertens L, Jaeggi ET. Diagnosis and management of fetal heart failure. Can J Cardiol 2013;29:759–67

Felker GM, Allen LA, Pocock SJ. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM program and the Duke databank. J Am Coll Cardiol 2007; 50:40e7.

Zöller B, Melander O, Svensson P, Engström G. Red cell distribution width for predicting cardiovascular disease: a literature review. EMJ Cardiol 2014;2:61-70.

Anderson JL, Ronnow BS, Horne BD. Usefulness of a complete blood count-derived risk score to predict incident mortality in patients with suspected cardiovascular disease. Am J Cardiol 2007; 99:169-74.

Oh J, Kang SM, Hong N. Relation between red cell distribution width with echocardiographic parameters in patients with acute heart failure. J Card Fail 2009;15:517-22.

Nikyar B, Sedehi M, Mirfazeli A, Qorbani M, Golalipour MJ. Prevalence and pattern of congenital heart disease among neonates in Gorgan, Northern Iran (2007-2008). Iranian J Pediatrics 2011:307-12.

Stephensen SS, Sigfusson G, Eiriksson H, Sverrisson JT, Torfason B, Haraldsson A, dkk. Congenital cardiac malformations in Iceland from 1990. Cardiol Young 2004;14:396-401.

Alabdulgader AAA. Congenital heart disease in Saudi Arabia: current epidemiology and future projections. East Mediter Health J 2006;12:S157-67.

Marielli AJ, Mackie AS, Ionescu-Ittu R Rahme E, Pilote L. Congenital heart disease in general population changing prevalence aged distribution. Circulation 2007;115:163-7.

Rahim F, Ebadi A, Saki G. Prevalence of congenital heart disease in iran: a clinical study. J Med Sci 2008;8:547-52.

Xue-young Y, Xiao-feng L, Xiao-dong L, Ying-long L. Incidence of congenital heart disease in Beijing, China. Chin Med J 2009;122:1128-32.

Mawlana W, Donia A, Elamrousy D. Relation between red cell distribution width and left ventricular function in children with heart failure. ISRN Pediatrics 2014;1-4.

Campbell M. Natural history of atrial septal defect. Brit Heart J 1970;32: 820–6.

Samanek M. Children with congenital heart disease: pro­bability of natural survival. Pediatric Cardiol 1992;13:152–8.

Popio KA, Gorlin R, Teichholz LE, Cohn PF, Bechtel D, Herman MV. Abnormalities of left ventricular function and geometry in adults with an atrial septal defect. Ventriculographic, hemodynamic and echocardiographic studies. Am J Cardiol 1975;36:302–8.

Bonow RO, Borer JS, Rosing DR, Bacharach SL, Green MV, Kent KM. Left ventricular functional reserve in adult patients with atrial septal defect: pre- and postoperative studies. Circulation 1981;63:1315–22.

Kim SJ. Geometric and functional change of both ventricles after atrial ventricular septal defect closure. J Cardiovasc Ultrasound 2014;22:180-1.

Gomez CA, Ludomirsky A, Ensing GJ, Rocchini AP. Effect of acute changes in load on left ventricular diastolic function during device closure of atrial septal defect. Am J Cardiol 2005;95:686-8.

Schroha AM, Laghezzaa LB, Domíngueza PJ, Brandána V, Nentoa DE. Echocardiographic Doppler evaluation of ventricular function in children with an atrial septal defect. Rev Esp Cardiol 2008;61:595-601.

Badesch DB, Champion HC, Sanchez MA, dkk. Diagnosis and assessment of pulmonary arterial hypertension. J Am Coll Cardiol 2009;54:55-66.

Gursoy M, Salihoglu E, Hatemi AC, Hokenek AF, Ozkan S, Ceyran H. Inflammation and congenital heart disease associated pulmonary hypertension. Heart Surg Forum 2015;18:E38-41.

McLaughlin VV, Archer SL, Badesch DB. ACCF/AHA 2009 Expert consensus document on pulmonary hypertension: a report of the american college of cardiology foundation task force on expert consensus documents and the american heart association developed in collaboration with the american college of chest physicians; american thoracic society, inc.; and the pulmonary hypertension association. J Am Coll Cardiol 2009;53:1573-619.

De Luca G, Venegoni L, Iorio S. Platelet distribution width and the extent of coronary artery disease: results from a large prospective study. Platelets 2010;21:508-14.




DOI: http://dx.doi.org/10.14238/sp18.5.2017.339-44

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