Korelasi Kadar Ion Kalsium Serum dengan Dimensi, Fungsi Sistol dan Diastol Ventrikel Kiri pada Thalassemia Mayor dengan Hemosiderosis
Sari
Latar belakang. Kalsium berperan penting dalam kontraksi miokardium. Besi bebas/non-transferrin bound iron (NTBI) pada
thalassemia mayor (TM) dengan kelebihan besi (hemosiderosis) masuk ke dalam sel jantung menggunakan L-typ e calcium channel
(LTCC) sehingga mengganggu transportasi kalsium.
Tujuan. Menganalisis korelasi kadar ion kalsium serum dengan dimensi, fungsi sistol, dan diastol ventrikel kiri pada TM yang
sudah mengalami hemosiderosis.
Metode. Penelitian potong lintang dilaksanakan dari Desember 2014–Januari 2015 melibatkan 67 kasus TMusia 7–14 tahun yang
disertai hemosiderosis. Pemeriksaan kadar ion kalsium serum menggunakan metode ion selective electrode (ISE) dan pemeriksaan
dimensi serta fungsi jantung menggunakan ekokardiografi 2 dimensi, M-mode, dan Doppler oleh dokter spesialis kardiologi anak.
Analisis korelasi dengan uji Spearman dan Pearson.
Hasil. Uji korelasi Spearman menunjukkan korelasi negatif yang signifikan antara kadar ion kalsium serum dan left ventricular
posterior wall thickness/LVPWd (r=-0,25; p=0,04). Uji korelasi Pearson menunjukkan korelasi negatif yang signifikan antara kadar
ion kalsium serum dan ejection fraction/EF (r=-0,294; p=0,016) serta fractional shortening/FS (r=-0,252; p=0,039), tetapi tidak
dengan fungsi diastol (p>0,05).
Kesimpulan. Semakin rendah kadar ion kalsium serum maka semakin tinggi nilai LVWP, EF, dan FS. Kadar ion kalsium serum
tidak berkorelasi dengan fungsi diastol.
Kata Kunci
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DOI: http://dx.doi.org/10.14238/sp17.3.2015.195-9
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